Strain Profile

Save

Bifidobacterium bifidum R0071

◔ Human-origin

Sequenced

Public genome assembly available

Bifidobacterium bifidum strain R0071 is a gram-positive anaerobic bacterium native to the human gastrointestinal tract. Research includes animal studies of its immunomodulatory and mucin-regulating effects, in vitro investigation of its interactions with human milk oligosaccharides, and randomized controlled trials examining its associations with changes in gut microbiota, immune function, and gastrointestinal symptoms in infants and healthy adults.

Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →

Share of this strain's 20 body-system-tagged papers that concern each system. Research coverage, not measured effect.

Gut 16 papers · 80%

Immune 11 papers · 55%

Metabolic 3 papers · 15%

Respiratory 2 papers · 10%

Liver 1 paper · 5%

Skin 1 paper · 5%

Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →

Share of this strain's 8 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

Diarrhea 4 papers · 50%

Weight & obesity 3 papers · 38%

Eczema / Atopic dermatitis 1 paper · 13%

Food allergies 1 paper · 13%

Respiratory infections 1 paper · 13%

Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →

24 papers reference this strain in the probiotic database.

Match confidence

Human Milk Oligosaccharide Synbiotic Alleviates Food Allergy in Mice by Modulating Gut Microbiota and Increasing Indole-3-lactic Acid Levels

· Journal of Agricultural and Food Chemistry

2025 OBSERVATIONAL

Early supplement of probiotics reduces the risk of obesity among preschool children: a real-world observational study

· Frontiers in Nutrition

Mapping probiotic interactions with human milk oligosaccharides

Bifidobacterial interactions with human milk oligosaccharides and their combined potential for the advancement of infant nutrition

· Cork Open Research Archive (University College Cork, Ireland)

Human milk oligosaccharide-sharing by a consortium of infant derived Bifidobacterium species

· Scientific Reports

In Vitro Probiotic Modulation of the Intestinal Microbiota and 2′Fucosyllactose Consumption in Fecal Cultures from Infants at Two Months of Age

· Microorganisms

O3 Changes in gut microbiota after synbiotic supplementation in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial

· Oral Presentations

Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study

· Beneficial Microbes

Modulatory effect of three probiotic strains on infants’ gut microbial composition and immunological parameters on a placebo-controlled, double-blind, randomised study

· Beneficial Microbes

Genome-Wide Immune Modulation of TLR3-Mediated Inflammation in Intestinal Epithelial Cells Differs between Single and Multi-Strain Probiotic Combination

Safety and tolerance of three probiotic strains in healthy infants: a multi-centre randomized, double-blind, placebo-controlled trial

· Beneficial Microbes

Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial

· Beneficial Microbes

Bifidobacterium bifidum R0071 results in a greater proportion of healthy days and a lower percentage of academically stressed students reporting a day of cold/flu: a randomised, double-blind, placebo-controlled study

· British Journal Of Nutrition

Bifidobacterium bifidum R0071 decreases stress‐associated diarrhea‐related symptoms and ultimately self‐reported stress in a randomized, double‐blind, placebo‐controlled study (647.21)

· The FASEB Journal

The proportion of stressed individuals who, on any given day, do not have a cold/flu may be increased by the intake of bifidobacteria: a randomized, double‐blind, placebo‐controlled study (639.13)

· The FASEB Journal

Multistrain Probiotic Modulation of Intestinal Epithelial Cells' Immune Response to a Double-Stranded RNA Ligand, Poly(I·C)

· Applied and Environmental Microbiology

2010 OBSERVATIONAL

Efficacy of a synbiotic supplementation in the prevention of common winter diseases in children: a randomized, double-blind, placebo-controlled pilot study

· Therapeutic Advances in Respiratory Disease

Immunomodulatory impact of a synbiotic in Th1 and Th2 models of infection

· Therapeutic Advances in Respiratory Disease

INTESTINAL MUCIN GENE MODULATION IN VIVO USING ORALLY ADMINISTERED PROBIOTIC BACTERIA

· Journal of Pediatric Gastroenterology and Nutrition

Precision synbiotic intervention with 2′-fucosyllactose and infant-derived Bifidobacterium modulates gut-immune axis and reduces disease risk in toddlers: a randomized controlled trial

· Frontiers in Nutrition

Browse all 24 papers →

Discussion

Be the first to comment.

Sign in to join the discussion.

No comments yet.

Citations

Selected papers that name this strain.

[1]

Precision synbiotic intervention with 2′-fucosyllactose and infant-derived Bifidobacterium modulates gut-immune axis and reduces disease risk in toddlers: a randomized controlled trial

· Frontiers in Nutrition · 2026

PMID 42598364 →
[2]

Mapping probiotic interactions with human milk oligosaccharides

· · 2025

Source →
[3]

Bifidobacterium bifidum R0071 decreases stress‐associated diarrhea‐related symptoms and ultimately self‐reported stress in a randomized, double‐blind, placebo‐controlled study (647.21)

· The FASEB Journal · 2014

Source →