Strain Profile
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Lactobacillus crispatus
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus crispatus is a lactic acid bacterium native to the human vaginal microbiota. Research has characterized the strain's genomic adaptation to host and body sites, and investigated its surface layer proteins and adhesion properties. Studies have examined the strain's role in vaginal dysbiosis, vulvovaginal candidiasis, and bacterial vaginosis in clinical and in vitro contexts. Comparative genomics have analyzed transport proteins and metabolomic properties across Lactobacillus species. The strain has been studied in animal models of vulvovaginal candidiasis.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 1,448 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 585 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+13 more symptoms
Strains of this species
3 strains of Lactobacillus crispatus in the index, with 63 linked papers between them.
Lactobacillus crispatus CTV-05
™ CTV-05
Lactobacillus crispatus CTV-05, marketed as LACTIN-V, is a vaginally administered live biotherapeutic product studied in one of the more extensive clinical development programs among probiotic strains.
Adhesion
AMR & toxins
Immune
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Food-origin
34 papers
0 comments
Lactobacillus crispatus M247
™ M247
Lactobacillus crispatus M247 is a rod-shaped lactic acid bacterium characterized by its mucus-binding properties and production of antimicrobial compounds.
Adhesion
Immune
Precision
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Food-origin
28 papers
0 comments
Lactobacillus crispatus LBV88
™ LBV88
Lactobacillus crispatus LBV88 is a vaginal-niche strain within L.
Adhesion
AMR & toxins
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Food-origin
1 papers
0 comments
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
2245 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
ANIMAL
2026
OTHER
2026
RCT
2026
REVIEW
2026
WGS
2026
WGS
2026
ANIMAL
2026
ANIMAL
2026
IN_VITRO
2026
WGS
2026
IN_VITRO
2026
IN_VITRO
2026
WGS
2026
OBSERVATIONAL
2026
OTHER
2026
OTHER
2026
IN_VITRO
2026
IN_VITRO
2026
IN_VITRO
2026
ANIMAL
Browse all 2,245 papers →
Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice
· Institutional Repositories DataBase (IRDB)
Vaginal Microbial Genome Collection (VMGC) MIDAS-compatible pangenome database
· Open MIND
Vaginal microbiota impacts of a Lactobacillus crispatus live biotherapeutic and predictors of colonization in randomized controlled trial
· Cell Host & Microbe
Unraveling the vaginal microbiota-based etiology of recurrent cystitis: the potential role of Lactobacillus vaginal suppositories
· Therapeutic Advances in Urology
Women’s health is a team effort: probiogenomics supports the development of a multi-species vaginal probiotic
· Cellular and Molecular Life Sciences
Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa
· bioRxiv (Cold Spring Harbor Laboratory)
Extracellular vesicles ameliorate intrauterine adhesion through Nrf2/GPX4-mediated ferroptosis suppression
· Journal of Advanced Research
Exploring the molecular crosstalk between the sex steroids drospirenone and ethinylestradiol with vaginal lactobacilli
· Frontiers in Microbiology
Strain-dependent effects of the probiotic Lactobacillus crispatus on the physicochemical, technological, nutritional, and antimicrobial characteristics of fermented milk formulated for women
· Applied Food Research
Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa
· npj Biofilms and Microbiomes
Lactobacillus crispatus attenuates Escherichia coli-induced inflammation and migration of cervical cancer cells
· AMB Express
Induction of Human β-Defensin-2 by Vaginal Lactobacillus crispatus Strains in Vaginal Epithelial Cells Correlates With Their Adhesion Abilities
· Open Forum Infectious Diseases
Postbiotics originated from Lactobacillus crispatus NCU-31 improves vulvar lichen sclerosus: a randomized, double-blind controlled trial
· BMC Microbiology
A comparative analysis of urinary microbiome identifies putative probiotics
· bioRxiv (Cold Spring Harbor Laboratory)
Lactobacillus crispatus (Brygoo and Aladame 1953) Moore and Holdeman 1970 emend. Cato et al. 1983
· BacDive
Use of Eutoplac for the Prevention of Septic Complications in Post-Bariatric Patients Undergoing Body Contouring Surgery
· Journal of Surgery Research and Practice
A microbiota–host axis mediates prostaglandin sensitivity: Lactobacillus crispatus as a biomarker and regulator of human labor induction
· npj Biofilms and Microbiomes
Machine learning-based prediction of BV-relevant probiotic functional potential in vaginal-derived Lactobacillus crispatus strains
· BMC Microbiology
Chicken-derived Lactobacillus strains alleviate Mycoplasma gallisepticum infection and improve growth performance in broilers
· Poultry Science
VIBRANT Trial primary and secondary outcomes processed data
· Zenodo (CERN European Organization for Nuclear Research)
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →VIBRANT Trial primary and secondary outcomes processed data· Zenodo (CERN European Organization for Nuclear Research) · 2026
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[2]
PMID 41903526 →Vaginal microbiota impacts of a Lactobacillus crispatus live biotherapeutic and predictors of colonization in randomized controlled trial· Cell Host & Microbe · 2026
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[3]
PMID 41566207 →Postbiotics originated from Lactobacillus crispatus NCU-31 improves vulvar lichen sclerosus: a randomized, double-blind controlled trial· BMC Microbiology · 2026
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[4]
PMID 42137495 →Unraveling the vaginal microbiota-based etiology of recurrent cystitis: the potential role of Lactobacillus vaginal suppositories· Therapeutic Advances in Urology · 2026
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[5]
PMID 41959050 →Characterisation of vaginal Lactobacillus isolates from South African women towards the development of a biotherapeutic to optimise the vaginal microbiome· bioRxiv (Cold Spring Harbor Laboratory) · 2026
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[6]
PMID 40194532 →Effect of the vaginal live biotherapeutic LACTIN-V (Lactobacillus crispatus CTV-05) on vaginal microbiota and genital tract inflammation among women at high risk of HIV acquisition in South Africa: a phase 2, randomised, placebo-controlled trial· The Lancet Microbe · 2025
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[7]
PMID 41050878 →Randomized trial of multi-strain Lactobacillus crispatus vaginal live biotherapeutic products after antibiotic therapy for bacterial vaginosis: study protocol for VIBRANT (vaginal lIve biotherapeutic RANdomized trial)· Contemporary Clinical Trials Communications · 2025
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[8]
PMID 40783570 →Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial· npj Biofilms and Microbiomes · 2025
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[9]
PMID 40428805 →The Vaginal Microbiota, Human Papillomavirus, and Cervical Dysplasia—A Review· Medicina · 2025
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[10]
PMID 40094958 →Cervicovaginal Microbiome: Physiology, Age-Related Changes, and Protective Role Against Human Papillomavirus Infection· Journal of Clinical Medicine · 2025