Strain Profile
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Lactobacillus kefiranofaciens
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus kefiranofaciens is a lactic acid bacterium originally isolated from kefir grains and best known as the primary producer of kefiran, the polysaccharide that gives kefir its characteristic gel-like texture. As a species, it has been studied in the context of kefir fermentation microbiology, and preliminary animal and in vitro research on kefiran has examined inflammatory and immune-related markers. Strain-specific published evidence for this particular entry is not represented in the current indexed literature, and the broader probiotic evidence for this species in humans remains limited. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 86 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+5 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 31 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
312 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
IN_VITRO
IN_VITRO
2026
ANIMAL
2026
ANIMAL
2026
WGS
2026
ANIMAL
2026
ANIMAL
2026
OTHER
2026
ANIMAL
2026
OTHER
2026
IN_VITRO
2025
IN_VITRO
2025
ANIMAL
2025
IN_VITRO
2025
ANIMAL
2025
ANIMAL
2025
IN_VITRO
2025
ANIMAL
2025
IN_VITRO
2025
REVIEW
Browse all 312 papers →
Kefiran Production Process by the Lactic Acid Bacterium Lactobacillus kefiranofaciens
乳酸菌Lactobacillus kefiranofaciensによるケフィラン生産プロセス
· Institutional Repositories DataBase (IRDB)
Production,structural characterization and biological activities of an exopolysaccharide kefiran produced by Lactobacillus kefiranofaciens WT-2BT
· Institutional Repositories DataBase (IRDB)
Probiotic Lactobacillus kefiranofaciens K6 attenuates physiological and behavioral alterations and modulates the gut microbiota in a mouse model of overtraining syndrome
· Food & Function
Therapeutic potential of Lactobacillus kefiranofaciens ZW18 postbiotic in alleviating hepatocellular carcinoma
· Food Research International
PanForge
· OSF Preprints (OSF Preprints)
Possible Involvement of NAMPT in the Anti-Obesity Effect of Oral Administration of Fermented Rice with Lactobacillus kefiranofaciens (Rice Kefiran) in C57BL/6J Mice
· International Journal of Molecular Sciences
Modulating gut microbiota to enhance anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: the role of Lactobacillus kefiranofaciens and SOCS3 regulation
· Oncogene
Lactobacillus kefiranofaciens subsp. kefiranofaciens (Fujisawa et al. 1988) Vancanneyt et al. 2004
· BacDive
Prebiotic augmented nanozyme-armored probiotics reprogramme the gut microenvironment for synchronous treatment of colitis and sepsis via antioxidant defense
· Journal of Advanced Research
Lactobacillus kefiranofaciens subsp. kefirgranum (Takizawa et al. 1994) Vancanneyt et al. 2004
· BacDive
Characterization of Mannose-Rich Exopolysaccharides from Kefir Lactic Acid Bacteria and Their Techno-Functional Potential in Fermented Milk
· Foods
Lactobacillus Kefiranofaciens Xz-54 Improves Antioxidant Activity and Flavor-Related Compounds in Fresh Cheese: Insights from Peptides and Metabolomics
· SSRN Electronic Journal
Developing a Novel Fermented Milk with Anti-Aging and Anti-Oxidative Properties Using Lactobacillus kefiranofaciens HL1 and Lactococcus lactis APL015
· Nutrients
Lactobacillus kefiranofaciens XZ-54 as adjunct culture: Enhancing antioxidant activity and flavor compounds in fresh cheese via peptidomic and metabolomic insights
· Food Bioscience
Immunoenhancing Effect of Lactobacillus Kefiranofaciens ZW18 Postbiotic On Cyclophosphamide-induced Immunosuppressed Mice
· Probiotics and Antimicrobial Proteins
The probiotic Lactobacillus kefiranofaciens K6 alleviates exercise and sleep deprivation-induced physiological dysregulation and neuropsychiatric disorders via modulation of inflammation, circadian rhythm, and stress response
· International Journal of Medical Sciences
Identification of dominant species common to kefir grains from seven origins for kefir grain reconstruction
· Journal of Dairy Science
Lactobacillus kefiranofaciens and its enhancement effect on the anti-inflammatory function of CII/Gln in MIA-induced osteoarthritis by protecting the intestinal barrier and gut microecology
· International Journal of Food Sciences and Nutrition
Milk composition shapes structural and microbial dynamics of kefir grain formation: Linking microbiota, metabolites, and grain architecture
· Journal of Dairy Science
Kefir-A Natural Fermented Probiotic-An Updated Review
· World Journal of Advanced Research and Reviews
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41752048 →Possible Involvement of NAMPT in the Anti-Obesity Effect of Oral Administration of Fermented Rice with Lactobacillus kefiranofaciens (Rice Kefiran) in C57BL/6J Mice· International Journal of Molecular Sciences · 2026
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[2]
PMID 42045535 →Modulating gut microbiota to enhance anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: the role of Lactobacillus kefiranofaciens and SOCS3 regulation· Oncogene · 2026
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[3]
PMID 41679603 →Prebiotic augmented nanozyme-armored probiotics reprogramme the gut microenvironment for synchronous treatment of colitis and sepsis via antioxidant defense· Journal of Advanced Research · 2026
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[4]
PMID 40959574 →The probiotic Lactobacillus kefiranofaciens K6 alleviates exercise and sleep deprivation-induced physiological dysregulation and neuropsychiatric disorders via modulation of inflammation, circadian rhythm, and stress response· International Journal of Medical Sciences · 2025
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[5]
Source →Kefir-A Natural Fermented Probiotic-An Updated Review· World Journal of Advanced Research and Reviews · 2025
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[6]
PMID 40806032 →Developing a Novel Fermented Milk with Anti-Aging and Anti-Oxidative Properties Using Lactobacillus kefiranofaciens HL1 and Lactococcus lactis APL015· Nutrients · 2025
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[7]
Source →Lactobacillus kefiranofaciens and Lactobacillus kefiri are the key species in kefir for reversing oxytetracycline-induced intestinal damage in zebrafish· Food Science and Human Wellness · 2024
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[8]
PMID 39796306 →Amelioration Effect of Lactobacillus kefiranofaciens ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB/c Mice· Foods · 2024
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[9]
PMID 39770698 →Rice Kefiran Ameliorates Obesity and Hepatic Steatosis Through the Change in Gut Microbiota· Microorganisms · 2024
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[10]
PMID 37601389 →Enhanced probiotic potential of Lactobacillus kefiranofaciens OSU-BDGOA1 through co-culture with Kluyveromyces marxianus bdgo-ym6· Frontiers in Microbiology · 2023