Strain Profile

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Lactobacillus murinus

◐ Food-origin

Sequenced

Public genome assembly available

Lactobacillus murinus is a bacterium native to the gastrointestinal tracts of rodents (rats and mice), where it is a dominant resident species. It is not a recognized human probiotic strain; its natural habitat is murine gut flora, and it appears in the human research literature primarily as a tool for studying gut-immune interactions in animal models. Preclinical animal studies have explored its potential roles in intestinal injury, inflammation, and liver fibrosis in mouse models. Human probiotic applications for this organism are not supported by clinical evidence, and findings from rodent models cannot be assumed to translate to humans.

Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →

Share of this strain's 180 body-system-tagged papers that concern each system. Research coverage, not measured effect.

Gut 157 papers · 87%

Immune 96 papers · 53%

Respiratory 21 papers · 12%

Brain & Mood 20 papers · 11%

Metabolic 16 papers · 9%

Oral 10 papers · 6%

+5 more systems

Cardiovascular 7 papers · 4%

Liver 6 papers · 3%

Bone & Joint 5 papers · 3%

Skin 1 paper · 1%

Vaginal 1 paper · 1%

Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →

Share of this strain's 59 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

Weight & obesity 12 papers · 20%

Oral health 10 papers · 17%

IBD 9 papers · 15%

Respiratory infections 8 papers · 14%

Diarrhea 6 papers · 10%

Depression 5 papers · 8%

+6 more symptoms

Anxiety 4 papers · 7%

Blood pressure 3 papers · 5%

High cholesterol 3 papers · 5%

H. pylori 3 papers · 5%

Allergic rhinitis 2 papers · 3%

IBS 1 paper · 2%

Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →

252 papers reference this strain in the probiotic database.

Match confidence

Lactobacillus murinus improves liver fibrosis in primary sclerosing cholangitis mice by decreasing taurocholic acid and regulating M2 macrophage polarization

· Journal of Biomedical Research

Sheng Jiangsan alleviated influenza-induced acute lung injury by regulating Lactobacillus murinus

· Journal of Ethnopharmacology

Loganic Acid Ameliorates Rheumatoid Arthritis via the Lactobacillus murinus‐Inodole‐3‐Acetic Acid– AhR – IL ‐10 Axis

· Phytotherapy Research

Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus

· Journal of drug targeting

Lactobacillus murinus Alleviates High Fructose‐Induced MASLD by Boosting Arginine Production

· Food Science & Nutrition

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

· iMetaOmics.

A naturally isolated symbiotic Lactobacillus murinus suppresses multidrug-resistant Campylobacter jejuni via microbial metabolites

· Current Research in Microbial Sciences

Lactobacillus murinus Reduces Susceptibility to Secondary MRSA Infection in IAV-Infected Mice Through Promoting a T Cell-Independent IgA Response

· Microorganisms

Lactobacillus murinus

Bangia fusco-purpurea polysaccharide exerts immunomodulatory effects through Lactobacillus murinus-mediated macrophage polarization via the MAPK/NF-κB-IL10 signaling axis 1

· Food Science and Human Wellness

The pulmonary commensal Lactobacillus regulated lung γδ T cells to enhance resistance against bacterial infections

· Microbiome

Lactobacillus murinus ZNL-13 Modulates Intestinal Barrier Damage and Gut Microbiota in Cyclophosphamide-Induced Immunosuppressed Mice

Muscone Ameliorates High-Altitude Hypoxia Gastrointestinal Stress via Modulation of Lactobacillus Murinus and Mitochondrial Metabolism

· Journal of Inflammation Research

Lactobacillus murinus Induces CYP1A1 Expression and Modulates TNF-Alpha-Induced Responses in a Human Intestinal Epithelial Cell Model

· International Journal of Molecular Sciences

Gut microbiota‐derived tryptophan metabolites improve total parenteral nutrition‐associated infections by regulating Group 3 innate lymphoid cells

Gut microbiota-derived xanthohumol protects against heatstroke by inhibiting macrophage pyroptosis in mice

· Journal of Advanced Research

Intestinal Lactobacillus murinus-derived small RNAs target porcine polyamine metabolism

· Proceedings of the National Academy of Sciences

Synergy between Lactobacillus murinus and anti-PcrV antibody delivered in the airways to boost protection against Pseudomonas aeruginosa

· Molecular Therapy — Methods & Clinical Development

Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N6-methyladenosine (m6A) mediated silencing of SLC7A11

· Ecotoxicology and Environmental Safety

Lactobacillus murinus alleviated lung inflammation induced by PAHs in mice

· Ecotoxicology and Environmental Safety

Browse all 252 papers →

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Citations

Selected papers that name this strain.

[1]

LACTOBACILLUS MURINUS ACTIVATES THE ARYL HYDROCARBON RECEPTOR TO ATTENUATE TNF-ALPHA-INDUCED PRO-INFLAMMATORY RESPONSES IN HUMAN INTESTINAL EPITHELIAL CELLS

· Inflammatory Bowel Diseases · 2022

Source →
[2]

Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1–Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria

· The Journal of Immunology · 2021

PMID 33827895 →
[3]

Salt-responsive gut commensal modulates TH17 axis and disease

· RePEc: Research Papers in Economics · 2017

Source →