Strain Profile
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Ligilactobacillus murinus

◔ Human-origin
Sequenced
Public genome assembly available

Ligilactobacillus murinus (formerly Lactobacillus murinus) is a lactic acid bacterium found predominantly in the gut microbiota of rodents and other small mammals. Most indexed research involves this species as an observed gut community member in animal model studies across a range of contexts — metabolism, immunity, sleep, antibiotic effects — rather than as a deliberately administered probiotic. A 2026 study explored extracellular vesicles derived from L. murinus in cell models in connection with inflammatory signaling, and the species has also been studied in a small canine randomized controlled trial using native LbP2 isolates. L. murinus is not an established human probiotic and does not have human clinical trial evidence; its relevance to human health is currently limited to mechanistic and correlational animal research. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 152 body-system-tagged papers that concern each system. Research coverage, not measured effect.

+4 more systems

Symptoms in the research

Share of this strain's 52 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

+8 more symptoms

Research

176 papers reference this strain in the probiotic database.

Match confidence
2026 OTHER
Sheng Jiangsan alleviated influenza-induced acute lung injury by regulating Lactobacillus murinus
· Journal of Ethnopharmacology
2026 OTHER
Elaidic acid suppresses hepatocellular carcinoma growth through modulating the production of intestinal Ligilactobacillus murinus-derived spermidine
· International Journal of Biological Sciences
2026 ANIMAL
Lactobacillus murinus improves liver fibrosis in primary sclerosing cholangitis mice by decreasing taurocholic acid and regulating M2 macrophage polarization
· Journal of Biomedical Research
2026 ANIMAL
Loganic Acid Ameliorates Rheumatoid Arthritis via the Lactobacillus murinus‐Inodole‐3‐Acetic Acid– AhR – IL ‐10 Axis
· Phytotherapy Research
2026 ANIMAL
Ligilactobacillus murinus confers a dual benefit: Counteracting crotonis fructus-induced intestinal toxicity and synergizing with its processed form against ulcerative colitis
· Journal of Ethnopharmacology
2026 OTHER
Elongation Factor Thermo Unstable Secreted Protein from Ligilactobacillus murinus 0516 Against Avian Infectious Bronchitis Virus
· Probiotics and Antimicrobial Proteins
2026 ANIMAL
Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance
· bioRxiv (Cold Spring Harbor Laboratory)
2026 ANIMAL
Lactobacillus murinus Alleviates High Fructose‐Induced MASLD by Boosting Arginine Production
· Food Science & Nutrition
2026 ANIMAL
Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling
· iMetaOmics.
2026 ANIMAL
The murine lung microbiome is dynamic and transient
· bioRxiv (Cold Spring Harbor Laboratory)
2026 ANIMAL
Raw data for Hansen et al. "Probiotic biogeography and sepsis prevention in the neonatal intestine".
· Figshare
2026 ANIMAL
Preventive intrapulmonary treatment with Ligilactobacillus murinus reduces airway inflammation and mucus plugging in mice with cystic fibrosis-like lung disease
· ERJ Open Research
2026 ANIMAL
Ovotransferrin Alleviates Ulcerative Colitis by Modulating Ligilactobacillus murinus-Mediated Bile Acid Metabolism via the Ptgs2/JAK-STAT Signaling Axis
· Journal of Agricultural and Food Chemistry
2026 OTHER
Probiotic Extracellular Vesicles from Ligilactobacillus murinus Alleviate Colonic Injury and Inflammation via miR-146a-5p-Driven Macrophage Polarization
· Food Bioscience
2025 ANIMAL
Multiple probiotic effects of Ligilactobacillus murinus strain S27 on large yellow croaker (Larimichthys crocea): Promoting growth, improving intestinal health, and enhancing resistance against Pseudomonas plecoglossicida
· Aquaculture
2025 ANIMAL
Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis
· Advanced Science
2025 ANIMAL
Leveraging probiotic biogeography to prevent dysbiosis in the neonatal intestine 4705
· The Journal of Immunology
2025 ANIMAL
Intestinal Dysbiosis Caused by Epithelial Fabp6 Gene Disruption Exacerbates Gut Inflammatory Disease
· Immune Network
2025 ANIMAL
Gut microbiota‐derived tryptophan metabolites improve total parenteral nutrition‐associated infections by regulating Group 3 innate lymphoid cells
· iMeta
2025 OBSERVATIONAL
Characterizing the microbiome of “sterile” organs in experimental mice and evidence of translocation of bacteria from the gut to other internal organs
· iMeta
Browse all 176 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
    · Cell Reports · 2024
    PMID 39500329 →
  2. [2]
    LACTOBACILLUS MURINUS ACTIVATES THE ARYL HYDROCARBON RECEPTOR TO ATTENUATE TNF-ALPHA-INDUCED PRO-INFLAMMATORY RESPONSES IN HUMAN INTESTINAL EPITHELIAL CELLS
    · Inflammatory Bowel Diseases · 2022
    Source →