Strain Profile · NCBI Species Taxon 1580
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Levilactobacillus brevis

◐ Food-origin
Sequenced
Public genome assembly available

Levilactobacillus brevis (formerly Lactobacillus brevis, species-level entry) is a lactic acid bacterium associated with fermented foods and studied for two principal properties: GABA (gamma-aminobutyric acid) production and antioxidant activity. GABA production during fermentation of plant-based substrates has been documented in multiple in vitro studies of various L. brevis strains, and antioxidant activity has been examined in an animal study of an L. brevis isolate. The species has also been investigated in vitro for antiviral activity against herpes simplex virus type 2 and for competitive exclusion of food pathogens. Evidence is largely strain-specific and in vitro or animal-based; human clinical evidence for this species-level entry is not available in the linked literature. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.

Where it's been studied

Share of this strain's 45 body-system-tagged papers that concern each system. Research coverage, not measured effect.

Gut 24 papers · 53%
Immune 21 papers · 47%
Oral 6 papers · 13%
Brain & Mood 4 papers · 9%
Liver 3 papers · 7%
Metabolic 3 papers · 7%
+4 more systems
Cardiovascular 2 papers · 4%
Skin 2 papers · 4%
Bone & Joint 1 paper · 2%
Vaginal 1 paper · 2%

Symptoms in the research

Share of this strain's 16 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.

Oral health 6 papers · 38%
High cholesterol 3 papers · 19%
Weight & obesity 3 papers · 19%
Depression 2 papers · 13%
Eczema / Atopic dermatitis 2 papers · 13%
Bloating & gas 1 paper · 6%
+1 more symptoms
H. pylori 1 paper · 6%

Research

146 papers reference this strain in the probiotic database.

Match confidence
2024 IN_VITRO
Efficacy of the Probiotic L. brevis in Counteracting the Demineralizing Process of the Tooth Enamel Surface: Results from an In Vitro Study
· Biomolecules
 2022 IN_VITRO
Effect of single probiotics Lacticaseibacillus casei CGMCC1.5956 and Levilactobacillus brevis CGMCC1.5954 and their combination on the quality of yogurt as fermented milk
· LWT
 2022 ANIMAL
Levilactobacillus brevis from carnivores can ameliorate hypercholesterolemia: In vitro and in vivo mechanistic evidence
· Journal of Applied Microbiology
 2021 IN_VITRO
Fruity aroma modifications in Merlot wines during simultaneous alcoholic and malolactic fermentations through mixed culture of S. cerevisiae, P. fermentans, and L. brevis
· LWT
 2021 IN_VITRO
Probiotic and Antifungal Attributes of Levilactobacillus brevis MYSN105, Isolated From an Indian Traditional Fermented Food Pozha
· Frontiers in Microbiology
 2021 IN_VITRO
Preparation and Functional Properties of Synbiotic Yogurt Fermented with Lactobacillus brevis PML1 Derived from a Fermented Cereal‐Dairy Product
· BioMed Research International
 2021 OTHER
Probiotic properties of novel probiotic Levilactobacillus brevis KU15147 isolated from radish kimchi and its antioxidant and immune-enhancing activities
· Food Science and Biotechnology
 2020 IN_VITRO
Probiotic Properties of Lactobacillus brevis KU200019 and Synergistic Activity with Fructooligosaccharides in Antagonistic Activity against Foodborne Pathogens
· Food Science of Animal Resources
 2020 IN_VITRO
Screening of GABA-Producing Lactic Acid Bacteria from Thai Fermented Foods and Probiotic Potential of Levilactobacillus brevis F064A for GABA-Fermented Mulberry Juice Production
· Microorganisms
 2020 IN_VITRO
Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis
· Pharmaceutics
 2020 IN_VITRO
Probiotic characteristics of Lactobacillus brevis B13-2 isolated from kimchi and investigation of antioxidant and immune-modulating abilities of its heat-killed cells
· LWT
 2020 OTHER
Aggregation, adherence, anti-adhesion and antagonistic activity properties relating to surface charge of probiotic Lactobacillus brevis gp104 against Staphylococcus aureus
· Microbial Pathogenesis
 2020 OTHER
Synbiotic yoghurt supplemented with novel probiotic Lactobacillus brevis KU200019 and fructooligosaccharides
· Food Bioscience
 2019 IN_VITRO
Rapid separation and identification of beer spoilage bacteria by inertial microfluidics and MALDI-TOF mass spectrometry
· Lab on a Chip
 2019 IN_VITRO
Probiotic characterization of Lactobacillus brevis KU15153 showing antimicrobial and antioxidant effect isolated from kimchi
· Food Science and Biotechnology
 2019 WGS
Comparative genome analysis of the Lactobacillus brevis species
· BMC Genomics
 2019 WGS
Genomic insights into a robust gamma-aminobutyric acid-producer Lactobacillus brevis CD0817
· AMB Express
 2019 IN_VITRO
Production of Functional Yogurt Drink, Apple and Orange Juice Using Nano-Encapsulated L. brevis Within Sodium Alginate-Based Biopolymers
· Science of Advanced Materials
 2019 ANIMAL
Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome
· Scientific Reports
 2019 IN_VITRO
Deciphering the crucial roles of transcriptional regulator GadR on gamma-aminobutyric acid production and acid resistance in Lactobacillus brevis
· Microbial Cell Factories
Browse all 146 papers →

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Citations

Selected papers that name this strain.

  1. [1]
    Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer: A randomized double-blind placebo-controlled study
    · European Journal of Cancer · 2011
    PMID 21741230 →
  2. [2]
    Anti‐inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease
    · Oral Diseases · 2007
    PMID 17577323 →