Strain Profile
Save
Bacteroides fragilis
◔
Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bacteroides fragilis is a gram-negative anaerobic bacterium that is a normal constituent of the human gut microbiome, though certain strains, particularly those carrying the B. fragilis toxin gene, are associated with opportunistic infections and diarrheal illness. The indexed research covers its role in glycan metabolism, mucin degradation, carbohydrate transport, virulence factors in intra-abdominal infection, and antibiotic susceptibility. A non-toxigenic variant, Bacteroides fragilis NCTC 9343, has attracted research interest in immune modulation (particularly polysaccharide A-mediated Treg induction), but the research in this catalog does not reflect dedicated probiotic studies. This species is cataloged here for microbiome completeness; clinical probiotic applications remain investigational. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 514 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 138 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
1219 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
ANIMAL
2025
REVIEW
2025
META_ANALYSIS
2025
ANIMAL
2025
WGS
2025
WGS
2025
ANIMAL
2025
ANIMAL
2025
ANIMAL
2025
ANIMAL
2025
META_ANALYSIS
2025
ANIMAL
2025
IN_VITRO
2025
REVIEW
2024
WGS
2024
OTHER
2024
REVIEW
2024
IN_VITRO
2024
ANIMAL
2024
ANIMAL
Browse all 1,219 papers →
Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2
· bioRxiv (Cold Spring Harbor Laboratory)
The metabolic and immunomodulatory functions of Bacteroides fragilis; a next-generation probiotic?
· Medicine in Microecology
Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence studies
· BMC Gastroenterology
Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis
· BMC Medicine
Genomic alterations in Bacteroides fragilis favor adaptation in colorectal cancer microenvironment
· BMC Genomics
Prophages in Bacteroides fragilis: Distribution and genetic diversity
· Heliyon
Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity
· Cell Host & Microbe
The therapeutic promise of probiotic Bacteroides fragilis (BF839) in cancer immunotherapy
· Frontiers in Microbiology
Bacteroides Fragilis Transplantation Reverses Reproductive Senescence by Transporting Extracellular Vesicles Through the Gut‐Ovary Axis
· Advanced Science
Growth Characteristics of Sheep-Derived Bacteroides fragilis and Preliminary Research on Effects in Mice and Lambs
· Microorganisms
Prevalence of enterotoxigenic Bacteroides fragilis in patients with colorectal cancer: a systematic review and meta-analysis
· Frontiers in Cellular and Infection Microbiology
Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease
· Journal of Crohn s and Colitis
Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives
· AMB Express
Biological Mechanisms of Enterotoxigenic Bacteroides fragilis Toxin: Linking Inflammation, Colorectal Cancer, and Clinical Implications
· Toxins
Pathogenic Bacteroides fragilis strains can emerge from gut-resident commensals
· bioRxiv (Cold Spring Harbor Laboratory)
Unveiling the mysteries: Functional insights into hypothetical proteins from Bacteroides fragilis 638R
· Heliyon
Nontoxigenic Bacteroides fragilis: A double-edged sword
· Microbiological Research
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1
· Protein & Cell
Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway
· Gut Microbes
Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic Bacteroides fragilis-Induced Colitis and Tumorigenesis
· Toxins
Discussion
Be the first to comment.
Sign in to join the discussion.
No comments yet.
Citations
Selected papers that name this strain.
-
[1]
PMID 40044987 →Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives· AMB Express · 2025
-
[2]
PMID 39930345 →Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence studies· BMC Gastroenterology · 2025
-
[3]
PMID 38494684 →A randomized trial of Bacteroides fragilis 839 on preventing chemotherapy-induced myelosuppression and gastrointestinal adverse effects in breast cancer patients.· PubMed · 2024
-
[4]
PMID 39330861 →Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic Bacteroides fragilis-Induced Colitis and Tumorigenesis· Toxins · 2024
-
[5]
PMID 39290561 →Efficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial· Frontiers in Nutrition · 2024
-
[6]
PMID 35404220 →A tale of two habitats: Bacteroides fragilis, a lethal pathogen and resident in the human gastrointestinal microbiome· Microbiology · 2022
-
[7]
Source →Clinical significance of Bacteroides fragilis as potential prognostic factor in colorectal cancer patients.· Journal of Clinical Oncology · 2022
-
[8]
PMID 34841788 →[Treatment of psoriasis vulgaris using Bacteroides fragilis BF839: a single-arm, open preliminary clinical study].· PubMed · 2021
-
[9]
PMID 34025663 →Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Bacteroides fragilis’ Polysaccharide A· Frontiers in Immunology · 2021
-
[10]
Source →Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice· UNC Libraries · 2020