Strain Profile
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Bacteroides thetaiotaomicron
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bacteroides thetaiotaomicron is a dominant member of the healthy human gut microbiome and one of the most extensively studied gut commensal bacteria. Its research profile focuses on complex polysaccharide metabolism, particularly the starch utilization system, which has made it a model organism for understanding how gut bacteria process dietary fiber. Animal research has explored its role in immune T cell modulation. B. thetaiotaomicron is not typically administered as a probiotic supplement in conventional products, and the indexed evidence is largely mechanistic and laboratory-based rather than clinical trial data; its importance lies in its central role in gut ecology. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 1,071 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 217 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+13 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
1680 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
IN_VITRO
2026
IN_VITRO
2026
OTHER
2026
ANIMAL
2026
ANIMAL
2026
OTHER
2026
IN_VITRO
2026
IN_VITRO
2026
OTHER
2026
WGS
2026
ANIMAL
2026
ANIMAL
2026
ANIMAL
2026
OTHER
2026
ANIMAL
2026
REVIEW
2026
OTHER
2026
IN_VITRO
2026
ANIMAL
2026
IN_VITRO
Browse all 1,680 papers →
Counterselection system employing mutated pheS for markerless genetic deletion in Bacteroides species
· Institutional Repositories DataBase (IRDB)
A system for transferring large genetic loci in Bacteroides enables hemicellulose utilization in Bacteroides thetaiotaomicron and characterization of a locus from an uncultivated strain
· Applied and Environmental Microbiology
Characterization of sphinganine acyltransferase and ceramide reductase in Bacteroides thetaiotaomicron
· Systems Microbiology and Biomanufacturing
Systemically delivered Bacteroides thetaiotaomicron-derived bacterial extracellular vesicles inhibit primary and metastatic melanoma growth
· bioRxiv (Cold Spring Harbor Laboratory)
Modulation of gut immunity and microbiota by Bacteroides thetaiotaomicron confers dose-dependent protection against necrotic enteritis in broiler chickens
· Poultry Science
Abstract 3552 Characterizing the Role of TonB-dependent Transporter BT4247 and Anti-Sigma Factor BT4248 to Better Understand Mucin Degradation in Bacteroides thetaiotaomicron
· Journal of Biological Chemistry
Structural and functional characterisation of the dextran utilisome from Bacteroides thetaiotaomicron
· bioRxiv (Cold Spring Harbor Laboratory)
A standardized toolkit for programmable protein secretion and surface display in Bacteroides thetaiotaomicron
· bioRxiv (Cold Spring Harbor Laboratory)
Abstract 3963 Characterization of TonB4 and TonB6 Proteins in Bacteroides thetaiotaomicron through generation of multiple gene deletion strains
· Journal of Biological Chemistry
The gut commensal Bacteroides thetaiotaomicron harbors prevalent class A and D β-lactamases with cross-taxa dissemination potential
· npj Biofilms and Microbiomes
Dual membrane-spanning anti-sigma 2 controls OMV biogenesis and colonization fitness in Bacteroides thetaiotaomicron
· Journal of Bacteriology
Microencapsulation of a novel Bacteroides thetaiotaomicron strain: a promising strategy to fortify intestinal barrier fortification in weaned pig model
· bioRxiv (Cold Spring Harbor Laboratory)
Monocolonization with Bacteroides thetaiotaomicron exerts region-specific effects on Alzheimer’s disease-related traits in the murine brain
· Microbiology Spectrum
Abstract 3548 Uncovering Polysaccharide Utilization Regulation: Interactions between Anti-Sigma Factors and TonB-Dependent Transporters in Bacteroides thetaiotaomicron
· Journal of Biological Chemistry
Bacteroides thetaiotaomicron (BT6) Restores Intestinal Homeostasis in Escherichia coli O157:H7-Challenged Mice
· Veterinary Sciences
Bacteroides thetaiotaomicron and Human Health: A Bibliometric Analysis of Global Research Trends.
· PubMed
An Engineered β-glucosidase from Bacteroides Thetaiotaomicron for Production of Rubusoside from Stevioside
· Applied Biochemistry and Biotechnology
Exploring the morphological heterogeneity of \(Bacteroides\) \(thetaiotaomicron\) using a low-input RNA-sequencing protocol
· Open MIND
Bacteroides thetaiotaomicron Improves Colorectal Cancer Prognosis by Remodeling the Immune Microenvironment
· Journal of Gastroenterology and Hepatology
Investigating the effect of ginger-derived nanovesicles on the growth and metabolic activity of Bacteroides thetaiotaomicron: an isothermal microcalorimetric study
· bioRxiv (Cold Spring Harbor Laboratory)
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41993214 →Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism· Frontiers in Immunology · 2026
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[2]
Source →Wheat Fiber Suppresses Colitis via Microbiota-Dependent Macrophage Reprogramming and Peripheral Regulatory T Cell Induction· Counseling And Psychological Services Dissertations (Georgia State University) · 2025
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[3]
PMID 40044987 →Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives· AMB Express · 2025
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[4]
PMID 40667442 →Effect of Bifidobacterium longum subsp. infantis YLGB-1496 on common diseases in pediatrics: a randomized, blinded, placebo-controlled trial· Frontiers in Nutrition · 2025
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[5]
PMID 32518945 →Host glycan utilization within the Bacteroidetes Sus-like paradigm· Glycobiology · 2020
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[6]
PMID 33464732 →A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn's Disease· Clinical and Translational Gastroenterology · 2020
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[7]
PMID 32513301 →Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease· Microbiome · 2020
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[8]
PMID 33260560 →Effects of Yeast Mannan Which Promotes Beneficial Bacteroides on the Intestinal Environment and Skin Condition: A Randomized, Double-Blind, Placebo-Controlled Study· Nutrients · 2020
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[9]
Source →Sa1905 – A Phase I Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Tolerability of (Thetanix®) Bacteroides Thetaiotaomicron in Adolescents with Stable Crohn’s Disease· Gastroenterology · 2019
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[10]
PMID 30561647 →Gut Microbiota as a Host Defender and a Foe: The 2 Faces of Commensal Bacteroides thetaiotaomicron in Inflammatory Bowel Disease· Inflammatory Bowel Diseases · 2018