Strain Profile
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Bacillus clausii
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Environmental
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bacillus clausii is a spore-forming bacterium studied as a potential probiotic organism in research. In vitro and animal studies have examined its tolerance to gastrointestinal transit stress, capacity for antibiotic biodegradation (cephalosporins), and antimicrobial protein production (laccase). Clinical research includes a randomized controlled trial in children with diarrhea and observational assessments in allergic rhinitis and small intestinal bacterial overgrowth. Additional research has investigated potential immunomodulatory pathways and applications in food fermentation, though documented cases of bacteremia have also been reported in the literature.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 311 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 158 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+13 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
569 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
RCT
2026
RCT
2026
OBSERVATIONAL
2026
OBSERVATIONAL
2026
RCT
2026
REVIEW
2026
IN_VITRO
2026
RCT
2026
IN_VITRO
2026
OTHER
2026
ANIMAL
2026
IN_VITRO
2026
IN_VITRO
2026
ANIMAL
2026
OTHER
2025
META_ANALYSIS
2025
IN_VITRO
2025
ANIMAL
2025
RCT
2025
OBSERVATIONAL
Browse all 569 papers →
P-114. Nasal-Spray Bacillus Spore Probiotics Prevent Respiratory Infections in Preschoolers: A Community RCT
· Open Forum Infectious Diseases
Efficacy and Safety of Bacillus clausii UBBC-07 in chronic kidney disease: a double-blind randomized placebo-controlled study
· International Journal of Probiotics and Prebiotics
Pharmacoeconomic and clinical effectiveness of intestinal microbiome correction in children with rotavirus gastroenteritis
· DSpace BSMU
Pharmaceutical care when using antidiarrheal microbial medicines for the correction of intestinal dysbiosis
· Social pharmacy in health care
Evaluation of Bacillus clausii Probiotic formulations in the Prevention of Antibiotic-Associated Diarrhea in Infants and Children: A Randomized, Double-Blind, Placebo-Controlled Study
· International Journal of Probiotics and Prebiotics
Beyond Diarrhea Control: Emerging Neuroimmune and Psychobiotic Roles of Bacillus clausii
· International Journal of Research in Pharmacy and Allied Science
Development of a Novel Multifunctional Probiotic Yogurt Fortified with Bacillus clausii and Carrot Powder with Enhanced Nutritional, Sensory, Rheological and Ultrastructural Properties
· Journal of Food and Dairy Sciences
Comparison of Reduction in Stool Frequency As Effect of Probiotics (Bacillus clausii) And Antisecretory (Racecadotril) in Acute Watery Diarrhea With Some / Mild Dehydration
· Journal of Health Wellness and Community Research
Microbial-enzyme synergistic treatment stabilizes surface microbial communities and enhances flavor quality during tobacco leaf aging
· Figshare
Accidental Intravenous Administration of Oral Bacillus clausii Probiotic (Enterogermina) in a Toddler: A Case Report
· Cureus
Potential Probiotic Effect of Bacillus clausii DM11 Isolate on Biological Parameters in Broiler Chickens
· Pakistan Veterinary Journal
Solvent‐Induced Modulation of Protease Catalysis: Kinetic and Thermodynamic Correlations With Polarity, Dielectric Constant and Solvatochromic Parameters
· International Journal of Chemical Kinetics
Engineering a Thermoresistant and Adaptable Nondigestible Carbohydrate Matrix With Bacillus clausii for Controlled Probiotic Delivery in Food Matrices
· Journal of Food Science
Probiotic Bacillus Clausii Protects against Amoxicillin-evoked Reproductive Dysfunction through Oxidative Stress Modulation
· Probiotics and Antimicrobial Proteins
A rare case of Bacillus clausii Bacteremia after an Inadvertent Intravenous Administration of Enterogermina® in an End-stage Renal Disease Patient Awaiting Renal Transplantation
· Journal of Clinical Infectious Disease Society
A Comprehensive Review and Meta-analysis on the Treatment of Acute Gastroenteritis in Children with a Bacillus clausii Preparation (Enterogermina®)
· Advances in Therapy
The Resistance Abilities of Some Bacillus Species to Gastrointestinal Tract Conditions: Whole Genome Sequencing of the Novel Candidate Probiotic Strains Bacillus clausii BA8 and Bacillus subtilis BA11
· Food Science & Nutrition
Preliminary evaluation of the effect of dietary supplementation of Bacillus clausii for adult healthy cats
· Italian Journal of Animal Science
Effectiveness of Zinc Supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii in Acute Watery Diarrhea in Pediatric Patients
· Proceedings of Shaikh Zayed Medical Complex Lahore
Bacteremia por Bacillus clausii em paciente adulto: relato de caso
· Journal Archives of Health
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →P-114. Nasal-Spray Bacillus Spore Probiotics Prevent Respiratory Infections in Preschoolers: A Community RCT· Open Forum Infectious Diseases · 2026
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[2]
Source →Beyond Diarrhea Control: Emerging Neuroimmune and Psychobiotic Roles of Bacillus clausii· International Journal of Research in Pharmacy and Allied Science · 2026
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[3]
Source →Efficacy and Safety of Bacillus clausii UBBC-07 in chronic kidney disease: a double-blind randomized placebo-controlled study· International Journal of Probiotics and Prebiotics · 2026
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[4]
Source →Evaluation of Bacillus clausii Probiotic formulations in the Prevention of Antibiotic-Associated Diarrhea in Infants and Children: A Randomized, Double-Blind, Placebo-Controlled Study· International Journal of Probiotics and Prebiotics · 2026
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[5]
Source →Comparison of Reduction in Stool Frequency As Effect of Probiotics (Bacillus clausii) And Antisecretory (Racecadotril) in Acute Watery Diarrhea With Some / Mild Dehydration· Journal of Health Wellness and Community Research · 2026
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[6]
Source →Impact of Probiotic Supplementation on duration of hospital stay in Preterm and Low Birth Weight Neonates In a Tertiary Care Centre: A Randomized Controlled Study· Journal of Neonatal Surgery · 2025
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[7]
PMID 40426506 →Effectiveness of Bacillus clausii (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review· Antibiotics · 2025
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[8]
PMID 40381158 →A Comprehensive Review and Meta-analysis on the Treatment of Acute Gastroenteritis in Children with a Bacillus clausii Preparation (Enterogermina®)· Advances in Therapy · 2025
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[9]
Source →Probiotics versus Rifaximin as Adjuvant Therapy for Helicobacter pylori Eradication· Afro-Egyptian Journal of Infectious and Endemic Diseases · 2025
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[10]
Source →COMPARISON OF WHO TREATMENT OF ACUTE WATERY DIARRHEA WITH OR WITHOUT PROBIOTIC (BACILLUS CLAUSII) IN TERM OF MEAN DURATION OF DIARRHEA IN CHILDREN· Zenodo (CERN European Organization for Nuclear Research) · 2025