Strain Profile
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Bifidobacterium longum BB536
DEP
BB536
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium longum strain BB536 is a gram-positive anaerobic bacterium native to the human gastrointestinal tract. Research includes in vitro studies of its antimicrobial activity against pathogenic organisms, animal studies examining its effects on the gut microbiota, and randomized controlled trials investigating its associations with changes in defecation frequency, biomarkers in hypercholesterolemia, and gastrointestinal function in various populations.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 138 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+4 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 68 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+12 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
201 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
ANIMAL
2026
RCT
2025
WGS
2025
OBSERVATIONAL
2025
RCT
2025
ANIMAL
2025
IN_VITRO
2024
RCT
2024
RCT
2023
ANIMAL
2023
OBSERVATIONAL
2023
IN_VITRO
2023
RCT
2023
ANIMAL
2022
IN_VITRO
2022
OBSERVATIONAL
2022
RCT
2022
RCT
2021
IN_VITRO
2021
RCT
Browse all 201 papers →
Bifidobacterium longum BB536 supplementation is associated with increased circulating choline plasmalogen concentrations in non-pregnant, non-lactating dairy cows
· Reproduction Fertility and Development
Bifidobacterium longum BB536 is associated with improvements in gastrointestinal symptoms and odor-related metabolites in microbiota-defined subgroups of male athletes consuming a high-protein diet: exploratory randomized double‑blind placebo‑controlled trial
· Journal of the International Society of Sports Nutrition
Single-cell comparative genomics: A novel approach to rigorous quality control via elucidating the existence of subpopulations in probiotic products
· Food Research International
Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study
· Gut Microbes Reports
Probiotic viability in the gastrointestinal tract in a randomised placebo controlled trial: combining molecular biology and novel cultivation techniques
· Beneficial Microbes
Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis
· Microorganisms
Propionibacterium freudenreichii co-inoculation enhances Bifidobacterium longum subsp. longum BB536 growth and metabolite content in soy whey
· The Microbe
Probiotic Bifidobacterium longum BB536 and its impact on subjective symptoms of physical conditions associated with common cold-like symptoms in healthy adults: A randomized, double-blind, placebo-controlled trial
· Journal of Functional Foods
The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled Trial
· Nutrients
Protective effect of Bifidobacterium longum BB536 against nausea caused by pirfenidone in a mouse model of pellagra
· Bioscience of Microbiota Food and Health
Efficacy and Safety of Synbiotics in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Randomized, Double-blinded, Placebo-controlled Pilot Study
· Internal Medicine
Growth and metabolic behavior of probiotic Bifidobacterium longum subsp. longum in minimally supplemented soy (tofu) whey
· Future Foods
The Potential Immunomodulatory Effect of Bifidobacterium longum subsp. longum BB536 on Healthy Adults through Plasmacytoid Dendritic Cell Activation in the Peripheral Blood
· Nutrients
Impact of Bifidobacterium longum BB536 on nausea caused by pirfenidone in a mouse model of pellagra
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Exploring the prebiotic potential of xanthan gum and its modified forms for the production of synbiotic yogurt
· Journal of Food Processing and Preservation
Efficacy and safety of synbiotics in patients undergoing autologous hematopoietic stem cell transplantation: A prospective, randomized, double-blind, placebo-controlled pilot study
· Research Square
Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial
· The American Journal of Gastroenterology
Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by Bifidobacterium longum BB536 supplementation: A RCT
· Computational and Structural Biotechnology Journal
Propotication with Bifidobacterium Longum BB536 into Different Sudanese Local Rice Types
· International Journal of Progressive Sciences and Technologies (Medical University Varna)
Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients.
· PubMed
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 39814039 →Probiotic viability in the gastrointestinal tract in a randomised placebo controlled trial: combining molecular biology and novel cultivation techniques· Beneficial Microbes · 2025
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[2]
Source →Probiotic Bifidobacterium longum BB536 and its impact on subjective symptoms of physical conditions associated with common cold-like symptoms in healthy adults: A randomized, double-blind, placebo-controlled trial· Journal of Functional Foods · 2024
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[3]
PMID 38201872 →The Potential Immunomodulatory Effect of Bifidobacterium longum subsp. longum BB536 on Healthy Adults through Plasmacytoid Dendritic Cell Activation in the Peripheral Blood· Nutrients · 2023
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[4]
PMID 36382178 →Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by Bifidobacterium longum BB536 supplementation: A RCT· Computational and Structural Biotechnology Journal · 2022
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[5]
Source →Improvement of defecation in elderly subjects by intake of a synbiotic food containing Bifidobacterium longum BB536: a randomized, open-label, parallel-group comparative trialBifidobacterium longum BB536 含有シンバイオティクス食品による高齢者の便通改善効果―ランダム化非盲検並行群間比較試験―· 薬理と治療 · 2020
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[6]
Source →Efficacy of drinking yogurt containing Bifidobacterium longum BB536 on perennial allergic rhinitis symptoms: a randomized, placebo-controlled, double-blind, parallel-group comparative trialビフィズス菌BB536 含有ドリンクヨーグルト摂取の通年性アレルギー性鼻炎症状に対する有効性―ランダム化プラセボ対照二重盲検並行群間比較試験―· 薬理と治療 · 2020
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[7]
Source →Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action· Journal of Functional Foods · 2019
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[8]
PMID 29065707 →Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children· Beneficial Microbes · 2017
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[9]
PMID 26418574 →Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double‐blinded, placebo‐controlled multicenter trial· Digestive Endoscopy · 2015
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[10]
PMID 20460726 →Effects of Bifidobacterium longum BB536 Administration on Influenza Infection, Influenza Vaccine Antibody Titer, and Cell-Mediated Immunity in the Elderly· Bioscience Biotechnology and Biochemistry · 2010