Strain Profile
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Lacticaseibacillus rhamnosus Lcr35
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lacticaseibacillus rhamnosus Lcr35 (formerly Lactobacillus casei rhamnosus Lcr35) has been evaluated in several randomized controlled trials across distinct clinical contexts, including pediatric chronic constipation, vaginal microbiome restoration following antibiotic treatment for bacterial vaginosis, and irritable bowel syndrome. In vitro and in vivo (C. elegans model) work has also examined antimicrobial properties against Candida albicans, with sulfur-containing compounds studied as possible contributors. Animal model research has examined the strain in the context of asthma and intestinal mucositis; these have not been confirmed in human trials. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 62 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+3 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 39 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
71 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2025
RCT
2024
META_ANALYSIS
2022
IN_VITRO
2022
IN_VITRO
2021
ANIMAL
2020
ANIMAL
2020
IN_VITRO
2020
IN_VITRO
2020
ANIMAL
2020
IN_VITRO
2020
IN_VITRO
2020
IN_VITRO
2019
IN_VITRO
2019
IN_VITRO
2019
OBSERVATIONAL
2019
IN_VITRO
2019
IN_VITRO
2019
IN_VITRO
2019
RCT
2018
RCT
Browse all 71 papers →
Enhanced sleep quality and reduced indoxyl sulfate levels following probiotic supplementation were linked to gut microbiota modulation in hemodialysis patients
· Journal of the Formosan Medical Association
Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials
· European Journal of Pediatrics
In vivo investigation of Lcr35® anti-candidiasis properties in Caenorhabditis elegans reveals the involvement of highly conserved immune pathways
· Frontiers in Microbiology
Lacticaseibacillus rhamnosus Lcr35 Stimulates Epithelial Vaginal Defenses upon Gardnerella vaginalis Infection
· Infection and Immunity
Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model
· Gastroenterology Research and Practice
Immune modulation effects and safety of Lactobacillus casei variety rhamnosus in a chemotherapy-induced intestinal mucositis mouse model
· Research Square (Research Square)
Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35
· Scientific Reports
Caractérisation in vivo des propriétés antimicrobiennes de la souche probiotique Lcr35®
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Combined Effects of Lactobacillus rhamnosus and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy
· Allergy Asthma and Immunology Research
Caractérisation in vivo des propriétés antimicrobiennes de la souche probiotique Lcr35
· theses.fr (ABES)
In vivo characterization of the antimicrobial properties of the probiotic strain Lcr35®
· theses.fr (ABES)
Caractérisation in vivo des propriétés antimicrobiennes de la souche probiotique Lcr35 ® Utilisation du modèle Caenorhabditis elegans pour l'étude des interactions hôte -microorganismes
· HAL (Le Centre pour la Communication Scientifique Directe)
Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights
· PLoS ONE
Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the preclinical model Caenorhabditis elegans
· HAL (Le Centre pour la Communication Scientifique Directe)
Therapy of bacterial vaginosis
· Meditsinskiy sovet = Medical Council
Lactobacillus rhamnosus Lcr35 en tant que traitement efficace contre l'infection à Candida albicans dans le modèle préclinique Caenorhabditis elegans
· HAL (Le Centre pour la Communication Scientifique Directe)
Lactobacillus rhamnosus Lcr35 ® as an effective treatment for preventing Candida albicans infection in preclinical models: first mechanistical insights
· bioRxiv (Cold Spring Harbor Laboratory)
Curative Treatment of Candidiasis by the Live Biotherapeutic Microorganism Lactobacillus rhamnosus Lcr35® in the Invertebrate Model Caenorhabditis elegans: First Mechanistic Insights
· Microorganisms
Traitement de l'aphtose buccale récidivante et idiopathique de l'adulte par probiotiques : étude interventionnelle randomisée en double aveugle versus placebo
· INRIA a CCSD electronic archive server
Comparative phase I randomized open-label pilot clinical trial of Gynophilus® (Lcr regenerans®) immediate release capsules versus slow release muco-adhesive tablets
· European Journal of Clinical Microbiology & Infectious Diseases
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Citations
Selected papers that name this strain.
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[1]
Source →Immune modulation effects and safety of Lactobacillus casei variety rhamnosus in a chemotherapy-induced intestinal mucositis mouse model· Research Square (Research Square) · 2020
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[2]
Source →Efficacy of a Triple Anti-Infective Regimen for Prevention of Complications in Critically Ill Term Neonates· Iranian Journal of Pediatrics · 2018
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[3]
PMID 22563194 →Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: A randomized, double-blind study· World Journal of Gastroenterology · 2012
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[4]
PMID 22773285 →Routine Probiotic Use in Very Preterm Infants: Retrospective Comparison of Two Cohorts· American Journal of Perinatology · 2012
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[5]
PMID 18823487 →The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis· BJOG An International Journal of Obstetrics & Gynaecology · 2008
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[6]
PMID 17587273 →Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation· Pediatrics International · 2007
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[7]
PMID 12624065 →Persistence of Colonization of Intestinal Mucosa by a Probiotic Strain, Lactobacillus casei subsp. rhamnosus Lcr35, after Oral Consumption· Journal of Clinical Microbiology · 2003