Strain Profile
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Lactobacillus acidophilus ATCC 4356
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus acidophilus ATCC 4356 is a reference strain used extensively in probiotic research as a standard comparator for adhesion, antimicrobial activity, and stress response studies. In vitro work has examined pathogen adhesion and invasion, such as Campylobacter jejuni, and bacteriocin production (antimicrobial peptides) in relation to competing bacteria including certain Bacillus species and dental pathogens. Animal model studies have examined parasitic infection and aflatoxin-related toxicity in fish, and the strain has been studied in simulated microgravity and mercury decontamination contexts. This research is exploratory and largely in vitro or in animal models; strain-specific human clinical data are limited. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 100 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 24 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
288 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
ANIMAL
2026
IN_VITRO
2026
IN_VITRO
2026
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IN_VITRO
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ANIMAL
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IN_VITRO
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IN_VITRO
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IN_VITRO
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ANIMAL
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IN_VITRO
2024
ANIMAL
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IN_VITRO
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IN_VITRO
Browse all 288 papers →
Probiotic and Postbiotic Interactions of Lactobacillus Strains with Candida albicans: Antifungal Effects Through Microbial Competition
· Antibiotics
Live–Postbiotic Multistrain Platform for Immune-Response Regulation and Barrier Restoration in Experimental Colitis
· International Journal of Public Health and Medical Research
PROBIOTIC GRANULE DEVELOPMENT FOR POTENTIAL PHYCOCYANIN AND LACTOBACILLUS ACIDOPHILUS ATCC 4356
· World Journal of Pharmacy and Pharmaceutical Sciences
Effect of Various Glucose Concentrations on Lactobacillus Species
· Balıkesır Health Sciences Journal
Impact of microencapsulation and milk matrix on Lactobacillus acidophilus survivalin yoghurt-based icecreams
· Czech Journal of Food Sciences
Bioactive Substances Derived From Probiotic Lactobacillus acidophilus Reduce Motility And Viability In Cervical Cancer Cells
· International Journal of Drug Delivery Technology
Effect of Dairy Powders and Sorbitol-Based Encapsulation Systems on Functional, Thermal, and Microstructural Quality of Probiotic Ice Cream
· Processes
Probiotics as Renal Guardians: Modulating Gut Microbiota to Combat Diabetes-Induced Kidney Damage
· Biology
Calcium modulates growth and biofilm formation of Lactobacillus acidophilus ATCC 4356 and Lactiplantibacillus plantarum ATCC 14917
· Scientific Reports
Microparticles of Pereskia aculeata miller mucilage and sodium alginate for the encapsulation of Lactobacillus acidophilus ATCC 4356
· International Journal of Biological Macromolecules
Tolerance of Probiotic Microorganisms to Sodium Chloride
· Journal of Research in Pharmacy
Lactobacillus acidophilus ATCC4356 inhibits thyroid cancer via E3 ubiquitin-protein ligase Mdm2 (MDM2)
· Turkish Journal of Biochemistry
Chemical Profile, Bioactive Constituents and In Vitro Growth Stimulation Properties of Cold-Pressed Hemp Seed Oils from Romanian Varieties: In Vitro and In Silico Evaluation
· Plants
JUMLAH KOLONI DAN DAYA HAMBAT YOGHURT CAMPURAN Streptococcus thermophilus DAN Lactobacillus acidophilus TERHADAP Propionibacterium acnes
· Medika Kartika Jurnal Kedokteran dan Kesehatan
Effects of Lactobacillus Acidophilus Mediated Improvement of Intestinal Barrier in Mice with Autism
· Probiotics and Antimicrobial Proteins
Inhibitory efficacy, production dynamics, and characterization of postbiotics of lactic acid bacteria
· BMC Microbiology
LACTOBACILLUS ACIDOPHILUS ATCC 4356 ALLEVIATES MYOCARDIAL ISCHEMIA-REPERFUSION INJURY THROUGH ANTI-APOPTOSIS, ANTIOXIDANT STRESS AND INHIBITS FERROPTOSIS RESPONSES
· Journal of the American College of Cardiology
Dietary Bioactive Compounds Trigger Distinct Epigenetic and Metabolic Reprogramming in Lactobacillus acidophilus
· bioRxiv (Cold Spring Harbor Laboratory)
Evaluation of Isolation Method of Exopolysaccharide Produced by Lactobacillus Acidophilus
· Journal of Biotechnology and its Applications
Mathematical Evaluation of Population Changes of Lactobacillus acidophilus and Bifidobacterium animalis ssp. lactis as Free and Encapsulated Cells in Butter
· Fermentation
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Citations
Selected papers that name this strain.
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[1]
Source →Impact of microencapsulation and milk matrix on Lactobacillus acidophilus survivalin yoghurt-based icecreams· Czech Journal of Food Sciences · 2026
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[2]
Source →PROBIOTIC GRANULE DEVELOPMENT FOR POTENTIAL PHYCOCYANIN AND LACTOBACILLUS ACIDOPHILUS ATCC 4356· World Journal of Pharmacy and Pharmaceutical Sciences · 2026
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[3]
Source →Live–Postbiotic Multistrain Platform for Immune-Response Regulation and Barrier Restoration in Experimental Colitis· International Journal of Public Health and Medical Research · 2026
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[4]
PMID 34794372 →Effectiveness of two probiotics in preventing necrotising enterocolitis in a cohort of very-low-birth-weight premature new-borns· Beneficial Microbes · 2021
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[5]
PMID 33133531 →Lead and cadmium biosorption from milk by Lactobacillus acidophilus ATCC 4356· Food Science & Nutrition · 2020
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[6]
PMID 29412508 →Proteomics Analysis of the Adhesion Activity of Lactobacillus acidophilus ATCC 4356 Upon Growth in an Intestine‐Like pH Environment· PROTEOMICS · 2018
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[7]
PMID 28650782 →Effect of Probiotic Yogurt and Xylitol-Containing Chewing Gums on Salivary S Mutans Count· Journal of Clinical Pediatric Dentistry · 2017
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[8]
Source →Inhibition of Colon Cancer in Mice by Microencapsulated Probiotic· · 2016
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[9]
PMID 19814836 →The probiotic Lactobacillus acidophilus reduces cholesterol absorption through the down-regulation of Niemann-Pick C1-like 1 in Caco-2 cells· British Journal Of Nutrition · 2009
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[10]
PMID 12522056 →Assessment of Safety of Lactobacillus Strains Based on Resistance to Host Innate Defense Mechanisms· Clinical and Vaccine Immunology · 2003