Strain Profile
· NCBI Strain Taxon
272621
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
How we classify this →
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Lactobacillus acidophilus NCFM
DEP
NCFM
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus acidophilus NCFM is a well-characterized probiotic strain studied across a range of laboratory and animal model contexts. In vitro research has examined intestinal epithelial barrier integrity and adhesion in the presence of opportunistic pathogens such as MRSA, while encapsulation studies have explored methods intended to affect its survival through the upper gastrointestinal tract. Animal model studies have examined gut microbiota, metabolic markers, and neurological outcomes, though these have not been confirmed in controlled human clinical trials. The research base for NCFM spans a range of topics for a named probiotic strain, but human clinical evidence remains limited. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 229 body-system-tagged papers that concern each system. Research coverage, not measured effect.
+5 more systems
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 76 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+12 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
351 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
RCT
2025
OTHER
2025
ANIMAL
2025
IN_VITRO
2025
WGS
2024
ANIMAL
2023
ANIMAL
2023
IN_VITRO
2023
IN_VITRO
2023
IN_VITRO
2022
ANIMAL
2022
RCT
2022
IN_VITRO
2021
ANIMAL
2021
IN_VITRO
2021
OBSERVATIONAL
2021
IN_VITRO
2021
IN_VITRO
2020
IN_VITRO
2020
RCT
Browse all 351 papers →
Lactobacillus acidophilus for infant colic and microbiota modulation: a randomized clinical trial
· BMC Pediatrics
Ab Initio Whole Cell Kinetic Model of Lactobacillus acidophilus NCFM (lacAS24)
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Differential modulation of post-antibiotic colonization resistance to Clostridioides difficile by two probiotic Lactobacillus strains
· mBio
Nutritional Strategies to Optimise the Probiotic Antimicrobial Efficacy of Lactobacillus acidophilus NCFM against Enteric Pathogens: Comparative Analysis between Natural Bee Honey and Mineralised Sugars
· East African Journal of Health and Science
The curated Lactobacillus acidophilus NCFM genome provides insights into strain specificity and microevolution
· BMC Genomics
A Synbiotic Combining Chitin–Glucan and Lactobacillus acidophilus NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an Animal Model of IBS
· International Journal of Molecular Sciences
Lactobacillus acidophilus NCFM and Lactiplantibacillus plantarum Lp-115 inhibit Helicobacter pylori colonization and gastric inflammation in a murine model
· Frontiers in Cellular and Infection Microbiology
Protein Concentration Affects the Food Allergen γ-Conglutin Uptake and Bacteria-Induced Cytokine Production in Dendritic Cells
· Biomolecules
Effect of Co-Fermentation of Saccharomyces boulardii CNCM-I745 with Four Different Probiotic Lactobacilli in Coffee Brews on Cell Viabilities and Metabolic Activities
· Fermentation
Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism
· Microorganisms
Evaluation of the Efficacy of Lactobacillus acidophilus in the Treatment ofCyclophosphamide-induced Hemorrhagic Cystitis in Wistar Rats
· Current Pharmaceutical Biotechnology
Lactobacillus acidophilus NCFM, Inulin, and Oat Bran Reduce TC and LDL-C in Adults with Hypercholesterolaemia
· Borneo Journal of Medical Sciences (BJMS)
Determining the Role of UTP-Glucose-1-Phosphate Uridylyltransferase (GalU) in Improving the Resistance of Lactobacillus acidophilus NCFM to Freeze-Drying
· Foods
In vivo transcriptome of Lactobacillus acidophilus and colonization impact on murine host intestinal gene expression
· Open MIND
The In Vitro Adsorption Ability of Lactobacillus acidophilus NCFM to Benzo(a)pyrene in PM2.5
· Journal of Toxicology
Ex vivo peripheral blood mononuclear cell response to R848 in children after supplementation with the probiotic Lactobacillus acidophilus NCFM/Bifidobacterium lactis Bi-07
· Beneficial Microbes
How do Lycium barbarum polysaccharides promote the adhesion of Lactobacillus to Caco-2 cells?
· Journal of Functional Foods
Nanofiber could deliver lactic acid bacteria to the intestine of ruminant in vitro experiment
· Journal of Animal Physiology and Animal Nutrition
S-layer associated proteins contribute to the adhesive and immunomodulatory properties of Lactobacillus acidophilus NCFM
· BMC Microbiology
Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study
· UNC Libraries
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 41998618 →Lactobacillus acidophilus for infant colic and microbiota modulation: a randomized clinical trial· BMC Pediatrics · 2026
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[2]
PMID 39754036 →The curated Lactobacillus acidophilus NCFM genome provides insights into strain specificity and microevolution· BMC Genomics · 2025
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[3]
PMID 37621875 →Lactobacillus acidophilus NCFM and Lactiplantibacillus plantarum Lp-115 inhibit Helicobacter pylori colonization and gastric inflammation in a murine model· Frontiers in Cellular and Infection Microbiology · 2023
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[4]
PMID 33505465 →The In Vitro Adsorption Ability of Lactobacillus acidophilus NCFM to Benzo(a)pyrene in PM2.5· Journal of Toxicology · 2021
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[5]
Source →In vivo transcriptome of Lactobacillus acidophilus and colonization impact on murine host intestinal gene expression· Open MIND · 2021
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[6]
PMID 32787778 →S-layer associated proteins contribute to the adhesive and immunomodulatory properties of Lactobacillus acidophilus NCFM· BMC Microbiology · 2020
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[7]
Source →İn Vitro Şartlarda Laktik Asit Bakterilerinin Ve Yoğurdun Kurşun Ve Kadmiyum Bağlama Özelliğinin İncelenmesi· Hacettepe University Institutional Repository (hacettepe.edu.tr) · 2018
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[8]
PMID 28980935 →Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial· Cellular and Molecular Biology · 2017
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[9]
PMID 28346730 →Cheese supplemented with probiotics reduced the Candida levels in denture wearers—RCT· Oral Diseases · 2017
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[10]
PMID 28780103 →Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli· Journal of Dairy Science · 2017