Strain Profile
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Lactobacillus acidophilus LA-5
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus acidophilus LA-5 is a commercially used probiotic strain studied primarily for its survivability in fermented food matrices such as yogurt, cheese, and whey-based beverages. The indexed literature is largely in vitro, focusing on growth characteristics, gastrointestinal transit tolerance, and synbiotic formulations with other probiotic species. One 2024 in vitro study explored apoptosis-related activity in a cancer cell model, though this work is early-stage and does not constitute clinical evidence of efficacy. Strain-specific human trial data is not present in the indexed literature.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 224 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 89 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+14 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
565 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
RCT
2026
ANIMAL
2026
OBSERVATIONAL
2026
IN_VITRO
2026
IN_VITRO
2026
IN_VITRO
2026
REVIEW
2026
IN_VITRO
2026
IN_VITRO
2026
IN_VITRO
2026
RCT
2026
IN_VITRO
2026
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
2025
ANIMAL
2025
IN_VITRO
2025
IN_VITRO
2025
IN_VITRO
Browse all 565 papers →
Exploring the immune modulatory effects of probiotics in autoimmune diseases
· International Journal of Immunology Research
Effects of paraprobiotic Lactobacillus acidophilus LA ‐5 on PANoptosis , oxidative stress and inflammation in acetic acid‐induced ulcerative colitis
· Journal of the Science of Food and Agriculture
Short-term synbiotic supplementation and intrahepatic triglyceride content assessed by proton MR spectroscopy: a pilot study
· BMC Gastroenterology
Food matrix matters: influence of milk type and fat content on Lactobacillus acidophilus LA-5 survival during storage and in vitro colonic fermentation
· Microbiology Australia
Multi-Analytical Approach for the Quality and Functional Evaluation of Probiotic Formulations: The Case of Lactobacillus acidophilus LA-5®Commercial Products
· Probiotics and Antimicrobial Proteins
Study of the Effect of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12 Probiotics on the Gut Microbiota Using an Artificial Gastrointestinal Tract Model
· Experimental and Clinical Gastroenterology
Probiotics in the ICU: a scoping review of evidence for infection prevention
· Journal of Translational Medicine
Probiotics in the induction of trained immunity
· National Archive of Doctoral Theses (National Documentation Center (Greece))
Microencapsulation of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12 in alginate and pectin, and the effects on bacterial acid and bile resistance
· Biotech Studies
Probiotic goat milk yogurt with plant-based prebiotics: Probiotic survival during in vitro simulated gastrointestinal transit
· Journal of Dairy Science
T‐Cell Populations in Infancy After Maternal Probiotic Supplementation to Prevent Atopic Dermatitis
· Clinical and Translational Allergy
Probiotic Cottage Cheese Formulated with Lactobacillus acidophilus LA-5: Microbial Viability, Acidification Kinetics, and Consumer Acceptance
· Recent Progress in Nutrition
Enhanced antimicrobial effect of thyme oil nanoemulsion combined with Lactobacillus acidophilus La-5 against Listeria monocytogenes in laboratory-prepared soft cheese
· Italian Journal of Food Science
Process development for TGase-assisted plant-based probiotic yogurt production with Lactobacillus acidophilus LA-5 and EU PDO Malatya apricot (Prunus armeniaca L.) kernel extract
· Applied Food Research
Spray-dried probiotic microcapsules with calcium cross-linked oxidized starch and inulin
· Carbohydrate Polymer Technologies and Applications
Viability of microencapsulated Lactobacillus acidophilus LA-5 with yeast cell wall and β-glucan in synbiotic Doogh (Iranian yoghurt drink) under simulated gastrointestinal conditions
· International Journal of Food Science & Technology
Cardioprotective Effect of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Is Mediated by Sarcolemmal but Not Mitochondrial ATP-Sensitive Potassium Channels in Rats with Systemic Inflammation
· International Journal of Molecular Sciences
Emerging Synbiotics Consisting of Catechin and Probiotic Bacteria: Exploring Aggregation, Adhesion, Antioxidant, and Anticancer Effects
· Probiotics and Antimicrobial Proteins
Interactions of Probiotics with the Immune Cells of Patients with COVID-19 Pneumonia
· Journal of Innate Immunity
Effect of yeast cell wall and β-glucan on survival of Lactobacillus acidophilus LA-5 encapsulated in spray-dried cross-linked alginate microcapsules
· LWT
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Citations
Selected papers that name this strain.
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[1]
PMID 42287602 →Multi-Analytical Approach for the Quality and Functional Evaluation of Probiotic Formulations: The Case of Lactobacillus acidophilus LA-5®Commercial Products· Probiotics and Antimicrobial Proteins · 2026
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[2]
PMID 42697830 →Effects of paraprobiotic Lactobacillus acidophilus LA ‐5 on PANoptosis , oxidative stress and inflammation in acetic acid‐induced ulcerative colitis· Journal of the Science of Food and Agriculture · 2026
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[3]
PMID 41491715 →Probiotics in the ICU: a scoping review of evidence for infection prevention· Journal of Translational Medicine · 2026
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[4]
Source →Exploring the immune modulatory effects of probiotics in autoimmune diseases· International Journal of Immunology Research · 2026
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[5]
PMID 41255078 →Probiotic Blend of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis ssp. Lactis BB‐12 in Non‐constipated Irritable Bowel Syndrome: A Double‐Blind Randomized Placebo‐Controlled Trial· Journal of Gastroenterology and Hepatology · 2025
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[6]
PMID 38658619 →A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome· Scientific Reports · 2024
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[7]
PMID 39102225 →Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants· JAMA Pediatrics · 2024
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[8]
PMID 38674780 →Lactobacillus acidophilus LA-5 Ameliorates Inflammation and Alveolar Bone Loss Promoted by A. actinomycetemcomitans and S. gordonii in Mice and Impacts Oral and Gut Microbiomes· Microorganisms · 2024
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[9]
PMID 36422363 →Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis· Microorganisms · 2022
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[10]
PMID 35807801 →A Four-Probiotic Regime to Reduce Surgical Site Infections in Multi-Trauma Patients· Nutrients · 2022