Strain Profile
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Lactobacillus plantarum 299v
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus plantarum 299v is one of the more studied probiotic strains in its species, with research spanning in vitro cell-interaction studies and observational work in human subjects. In vitro studies have examined pathogen biofilm formation and inflammatory signaling in intestinal cell models; reviews have explored the strain in the context of irritable bowel syndrome (IBS), a functional digestive condition. Available evidence is preliminary and predominantly laboratory-based, and results from clinical reviews have been mixed. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 176 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 84 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+11 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
263 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
REVIEW
2026
RCT
2025
REVIEW
2025
RCT
2025
ANIMAL
2025
IN_VITRO
2025
IN_VITRO
2025
ANIMAL
2025
REVIEW
2025
IN_VITRO
2025
IN_VITRO
2025
META_ANALYSIS
2025
REVIEW
2025
IN_VITRO
2024
IN_VITRO
2024
RCT
2024
RCT
2024
ANIMAL
2024
RCT
2024
IN_VITRO
Browse all 263 papers →
TS Case Study: Effect of Probiotic Supplementation on Endothelial Function II - A Translational Science Benefits Model Case Study
· Zenodo (CERN European Organization for Nuclear Research)
The Impact of Lactobacillus plantarum 299v as a Probiotic in Iron-deficiency Anemia Patients
· Journal of Applied Hematology
Probióticos en la modulación de los síntomas del síndrome de intestino irritable: revisión bibliográfica.
· MQRInvestigar
The effect of a sustainable diet and time-restricted eating and probiotic in heart failure with reduced ejection fraction patients: study protocol for a randomized, double-blind, and placebo-controlled trial
· Nutrition Journal
Can Iron Absorption in Molasses Be Increased with Probiotic Additives? “Molasses with Increased Bioavailability”
· Nutrients
Characterization of Selenium Accumulation in Lactiplantibacillus plantarum Strains: A Biotechnological Approach
· International Journal for Vitamin and Nutrition Research
Probiotic bacterial supplements play an immunomodulatory role by stimulating IL-22 and IL-37 in breast cancer cell lines.
· Microbes and Infectious Diseases /Microbes and Infectious Diseases
Lactiplantibacillus plantarum Intake Reduces Gastrointestinal Tract Damage Caused by Chronic Stress in Young Rats
· ACS Omega
Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review
· Nutrients
Synbiotic yoghurt with Lactiplantibacillus plantarum and plant powder substrates
· Czech Journal of Food Sciences
Synergistic Effects of Microalgae and Probiotic Additives in Edible Coatings on Strawberry Storage Quality: Experimental and Molecular Docking Studies
· Probiotics and Antimicrobial Proteins
Not All Probiotics Are Equal: Strain-Specific Effects on IBS Symptoms
· International Journal of Pharmaceutical Sciences Review and Research
Probiotic Use in Irritable Bowel Syndrome (IBS) Comprehensive Review
· International Journal of Scientific Research and Innovative Studies
Enhancing Malva sylvestris extract properties through lactic acid bacteria fermentation: impact on phytochemical profile and bioactivity
· Food Production Processing and Nutrition
The Possibility of Using Lactobacillus plantarum 299v to Reinforce the Bioactive Properties of Legume-Derived Beverages
· Applied Sciences
Probiotic Lactobacillus plantarum 299v supplementation in patients with major depression in a double-blind, randomized, placebo-controlled trial: A metabolomics study
· Journal of Affective Disorders
ReFerm®: a postbiotic fermented oat gruel composition is reducing mast cell degranulation in the colon of patients with irritable bowel syndrome
· Frontiers in Medicine
Lactobacillus plantarum 299v administration prevents high-sodium diet-induced glycocalyx degradation and arterial dysfunction
· Physiology
Improved gastrointestinal tolerance and iron status via probiotic use in iron deficiency anaemia patients initiating oral iron replacement: a randomised controlled trial
· British Journal Of Nutrition
Impact of baby spinach as a carrier for the development of sustainable probiotics prior to consumption
· Frontiers in Sustainable Food Systems
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →The Impact of Lactobacillus plantarum 299v as a Probiotic in Iron-deficiency Anemia Patients· Journal of Applied Hematology · 2026
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[2]
Source →TS Case Study: Effect of Probiotic Supplementation on Endothelial Function II - A Translational Science Benefits Model Case Study· Zenodo (CERN European Organization for Nuclear Research) · 2026
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[3]
Source →Not All Probiotics Are Equal: Strain-Specific Effects on IBS Symptoms· International Journal of Pharmaceutical Sciences Review and Research · 2025
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[4]
Source →Probióticos en la modulación de los síntomas del síndrome de intestino irritable: revisión bibliográfica.· MQRInvestigar · 2025
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[5]
Source →Probiotic Use in Irritable Bowel Syndrome (IBS) Comprehensive Review· International Journal of Scientific Research and Innovative Studies · 2025
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[6]
PMID 40218922 →Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review· Nutrients · 2025
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[7]
PMID 39494607 →Improved gastrointestinal tolerance and iron status via probiotic use in iron deficiency anaemia patients initiating oral iron replacement: a randomised controlled trial· British Journal Of Nutrition · 2024
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[8]
Source →Strain-Specific and Outcome-Specific Efficacy of Probiotics for the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis· SSRN Electronic Journal · 2021
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[9]
PMID 33597583 →Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation· Scientific Reports · 2021
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[10]
PMID 33613097 →The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases· Central European Journal of Immunology · 2021