Strain Profile
· NCBI Strain Taxon
220668
NCBI Taxonomy's node for this specific strain. A different identifier from the culture-collection deposit numbers below, which name a physical stock rather than a taxonomic node.
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Lactobacillus plantarum WCFS1
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
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Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus plantarum WCFS1 is one of the most extensively characterized probiotic reference strains, with a fully sequenced and reannotated genome that has made it a workhorse for understanding how lactobacilli interact with their environment. In vitro studies have examined its stress-resistance mechanisms, including acid tolerance, oxidative stress management, and protein glycosylation, as well as its capacity to produce enzymes that deglycosylate dietary flavonoids such as rutin and naringin. More recent laboratory research has examined WCFS1 embedded in pectin-based encapsulation systems in relation to gut epithelial wound healing in cell culture models; these findings are preliminary and have not been evaluated in human studies. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 170 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 28 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
372 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2025
WGS
2025
IN_VITRO
2025
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2024
IN_VITRO
2023
IN_VITRO
2023
ANIMAL
2022
IN_VITRO
2022
IN_VITRO
2022
IN_VITRO
2022
OTHER
2021
REVIEW
2021
IN_VITRO
Browse all 372 papers →
A c-di-AMP receptor mediates epithelial adhesion of Lactiplantibacillus plantarum
· Nature Communications
PHASTEST-Based Prophage Mapping and Functional Analysis of Lactiplantibacillus plantarum WCFS1
· Journal of Dairy Science and Biotechnology
A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP
· Nature Communications
Lactobacillus plantarum in high methoxylated pectin-based encapsulation systems supports gut epithelial wound healing in vitro
· Food Hydrocolloids for Health
Exploring Lactiplantibacillus plantarum biofilm formation and the impact of biotic, environmental and physical factors
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Comparison of iPSC-derived human intestinal epithelial cells with Caco-2 cells and human in vivo data after exposure to Lactiplantibacillus plantarum WCFS1
· Scientific Reports
Mechanistic study of the differences in lactic acid bacteria resistance to freeze- or spray-drying and storage
· Applied Microbiology and Biotechnology
A novel “microbiota-host interaction model” to study the real-time effects of fermentation of non-digestible carbohydrate (NDCs) on gut barrier function
· Current Research in Food Science
Select Probiotics Exhibit Antioxidative and Anti-Inflammatory Properties for Gut Modulation: In Vitro Analysis
· The EuroBiotech Journal
Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
· Microorganisms
Pectin-based encapsulation systems for the protection of beneficial bacterial species and impact on intestinal barrier function in vitro
· Food Hydrocolloids
Removal of raffinose and stachyose from soy-based beverages using soluble and immobilized MelA α-D-galactosidase from Lactiplantibacillus plantarum WCFS1
· LWT
Non-redundant functionality of Lactiplantibacillus plantarum phospho-β-glucosidases revealed by carbohydrate utilization signatures associated to pbg2 and pbg4 gene mutants
· Journal of Applied Microbiology
Elucidation of the Tissue Distribution and Host Immunostimulatory Activity of Exogenously Administered Probiotic-Derived Extracellular Vesicles for Immunoadjuvant
· Molecular Pharmaceutics
Deciphering the Myrosinase-like Activity of Lactiplantibacillus plantarum WCFS1 among GH1 Family Glycoside Hydrolases
· Journal of Agricultural and Food Chemistry
Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections
· Microbial Biotechnology
Pulsed Electric Field Pre-treatment for Spray Drying of Probiotics
· Proceedings of the 22nd International Drying Symposium on Drying Technology - IDS '22
Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction
· bioRxiv (Cold Spring Harbor Laboratory)
The Possible Link Between Manufacturing and Probiotic Efficacy; a Molecular Point of View on Bifidobacterium
· Frontiers in Microbiology
Construction of an Integrated mCherry Red Fluorescent Protein Expression System for Labeling and Tracing in Lactiplantibacillus plantarum WCFS1
· Frontiers in Microbiology
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Lactobacillus plantarum in high methoxylated pectin-based encapsulation systems supports gut epithelial wound healing in vitro· Food Hydrocolloids for Health · 2025
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[2]
PMID 38837050 →Mechanistic study of the differences in lactic acid bacteria resistance to freeze- or spray-drying and storage· Applied Microbiology and Biotechnology · 2024
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[3]
PMID 38681527 →A novel “microbiota-host interaction model” to study the real-time effects of fermentation of non-digestible carbohydrate (NDCs) on gut barrier function· Current Research in Food Science · 2024
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[4]
Source →Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction· bioRxiv (Cold Spring Harbor Laboratory) · 2022
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[5]
Source →Mehanizmi aktivacije naravne imunosti celic črevesnega epitelija z izbranimi probiotičnimi sevi bakterij· Repository of the University of Ljubljana (University of Ljubljana) · 2019
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[6]
PMID 29379071 →L. plantarum WCFS1 enhances Treg frequencies by activating DCs even in absence of sampling of bacteria in the Peyer Patches· Scientific Reports · 2018
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[7]
PMID 28045137 →The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial· Scientific Reports · 2017
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[8]
PMID 28878772 →Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells· Frontiers in Immunology · 2017
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[9]
PMID 27231133 →Lactobacillus plantarum WCFS 1 and its host interaction: a dozen years after the genome· Microbial Biotechnology · 2016
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[10]
PMID 24023646 →Chronic HIV Infection Enhances the Responsiveness of Antigen Presenting Cells to Commensal Lactobacillus· PLoS ONE · 2013