Strain Profile
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Lactobacillus helveticus
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Food-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Lactobacillus helveticus is a lactic acid bacterium widely used in dairy fermentation and probiotic applications. Research has examined its capacity to produce bioactive peptides from milk proteins in vitro, its immunomodulatory properties via extracellular polysaccharides in cell culture, and its effects in animal models of gastrointestinal and metabolic health, including assessments in randomized controlled trials of acute infectious gastroenteritis.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 819 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 453 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+17 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
3431 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
2026
IN_VITRO
2026
ANIMAL
2026
ANIMAL
2026
OTHER
2026
IN_VITRO
2026
OTHER
2026
IN_VITRO
2026
ANIMAL
2026
IN_VITRO
2026
IN_VITRO
2026
OTHER
2026
IN_VITRO
2026
IN_VITRO
2026
OTHER
2026
RCT
2026
IN_VITRO
2026
OTHER
2026
IN_VITRO
2026
RCT
2026
IN_VITRO
Browse all 3,431 papers →
Acid adaptation of Lactobacillus helveticus during continuous cultures to improve undissociated lactic acid production
· Bioresources and Bioprocessing
Lactobacillus helveticus R0052-derived membrane vesicles ameliorate DSS-induced inflammatory bowel disease by modulating the gut microbiota and activating the cholinergic anti-inflammatory pathway
· International Immunopharmacology
A Functional Beverage Containing Lactobacillus helveticus and Mosla chinensis Maxim Supports Respiratory Health In Vitro
· Alternative Complementary & Integrative Medicine
Adaptive evolution of Lactobacillus helveticus enhances acid tolerance for food-grade, non-GMO applications
· Food Research International
In vitro Anti-biofilm Activity of Lactobacillus helveticus on Clinical Isolates of MultiDrug Resistant Klebsiella pneumoniae species
· The Egyptian Journal of Medical Microbiology
Microbial Biomarkers for the Prevention and Diagnosis of Alcoholic Liver Disease
· Microorganisms
Enhancing the shelf life and biofunctional properties of whey-based cultured buttermilk using spice powder and oleoresin
· International Journal of Agriculture and Food Science
The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles
· Figshare
Effects of Lactobacillus helveticus H11 Addition on the Fermentation, Storage, and Probiotic Properties of Brown Fermented Milk
· Foods
Functional, Modeling and Antimicrobial Characterization of Lactobacillus helveticus BGRA43 Isolated from Traditional Iranian Cheese
· Probiotics and Antimicrobial Proteins
Whey from fermented milk by Lactobacillus helveticus CCFM1263 alleviates osteoporosis
· Food Bioscience
Genomic and functional analysis of stress-responsive prophages in Lactobacillus helveticus
· Frontiers in Microbiology
Effects of fermentation by Lactobacillus helveticus on the quality and anti-inflammatory potential prediction of pumpkin juice during storage
· Food Chemistry X
Lactobacillus helveticus (Orla-Jensen 1919) Bergey et al. 1925
· BacDive
Effects of supplementation with two probiotic strains on metabolic profile, hormonal status, oxidative stress, and quality of life in women with polycystic ovary syndrome: A study protocol for a randomized clinical trial
· International Journal of Reproductive BioMedicine (IJRM)
Computational Assessment of Lactobacillus helveticus and Bifidobacterium longum Metabolites for Perinatal Depression Therapy
· Bacteria
Metagenomic analysis of lactic acid bacteria communities in inner Mongolian fermented dairy products: influence of milk source and geography
· Food Research International
In vitro prebiotic assessment of pectin, inulin and fructooligosaccharide on probiotic lactic acid bacteria
· International Journal of Agriculture and Food Science
Efficacy of Adjunct PRObiotics as Compared to the Standard Care in Moderate Unipolar Depression Among Geriatric Patients: A Randomized Double‐Blind Placebo‐Controlled Pilot Multi‐Center Trial (PRODG)
· Journal of the American Geriatrics Society
Personalized barrier recovery induced by Lactobacillus helveticus SBT2171 in an In Vitro model of ulcerative colitis-derived fecal supernatants
· BMC Complementary Medicine and Therapies
Discussion
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Citations
Selected papers that name this strain.
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[1]
PMID 42304935 →Efficacy of Adjunct PRObiotics as Compared to the Standard Care in Moderate Unipolar Depression Among Geriatric Patients: A Randomized Double‐Blind Placebo‐Controlled Pilot Multi‐Center Trial (PRODG)· Journal of the American Geriatrics Society · 2026
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[2]
PMID 41751175 →Lactobacillus helveticus UA881 Improves Body Composition, Lipid Profiles, and Gut Microbiota in Overweight Adults: A Randomized Double-Blind Placebo-Controlled Trial· Biomedicines · 2026
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[3]
PMID 42231513 →Safety evaluation of the long-term intake of heat-killed Lactobacillus helveticus MCC1848 in healthy adults: a randomized, double-blind, placebo-controlled study· BMC Nutrition · 2026
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[4]
PMID 41710512 →Novel probiotic Lactobacillus helveticus WIS02 alleviates diabetes through multi-pronged regulation of glycolipid metabolism, pancreatic protection and gut microbiota remodeling· Frontiers in Microbiology · 2026
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[5]
PMID 41512794 →Lactobacillus helveticus R0052-derived membrane vesicles ameliorate DSS-induced inflammatory bowel disease by modulating the gut microbiota and activating the cholinergic anti-inflammatory pathway· International Immunopharmacology · 2026
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[6]
PMID 40849096 →Lactobacillus helveticus R0052 attenuates DSS-induced colitis via modulation of gut microbiota, intestinal metabolites and immunological profiles in a mouse model· Microbial Pathogenesis · 2025
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[7]
PMID 40935392 →A Mechanistic Study of Lactobacillus helveticus HY7801 and Its Extracellular Vesicles in Premenstrual Syndrome: Role of Gut Microbiota and Hormonal Modulation· Journal of Microbiology and Biotechnology · 2025
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[8]
Source →Lactobacillus helveticus GCL1815 induces salivary IgA production and alleviates common cold-like symptoms: A randomized, double-blind, placebo-controlled, parallel-group comparative study· Journal of Functional Foods · 2025
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[9]
PMID 39920878 →The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind, placebo-controlled clinical trial· Journal of Health Population and Nutrition · 2025
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[10]
PMID 38172876 →Synbiotic as an ameliorating factor in the health-related quality of life in women with polycystic ovary syndrome. A randomized, triple-blind, placebo-controlled trial· BMC Women s Health · 2024