Strain Profile
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Bifidobacterium infantis
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Human-origin
Where this strain was first isolated, curated from the literature and culture-collection catalogs. It describes provenance only — not suitability, and not benefit.
How we classify this →
Sequenced
Whether a public genome assembly is linked for this strain. Without one the genome screens cannot run. It is not a verdict on the organism.
How we classify this →
Public genome assembly available
Bifidobacterium infantis is an anaerobic bacterium native to the infant gut microbiota. Research has examined the strain's potential mechanisms related to intestinal barrier function and immune tolerance, including effects on tight junction proteins and dendritic cell signaling. Animal models have examined intestinal health outcomes, and the strain's metabolism of human milk oligosaccharides has been characterized in vitro. Human clinical evidence remains limited, with most mechanistic research conducted in preclinical models. These are research topics, not findings; the papers do not establish that this strain treats or prevents any condition.
Where it's been studied Tags come from a conservative keyword scan of each paper's title, abstract, and summary. A tag is research coverage, not measured effect. How we classify this →
Share of this strain's 878 body-system-tagged papers that concern each system. Research coverage, not measured effect.
Symptoms in the research A tag means the paper's text names the symptom or condition — research coverage, not evidence of benefit. How we classify this →
Share of this strain's 281 symptom-tagged papers that mention each symptom or condition. Research coverage, not evidence of benefit.
+15 more symptoms
Research Study-type filters use AI-classified labels, audited but not guaranteed — check the paper itself before leaning on one. How we classify this →
1349 papers reference this strain in the probiotic database.
Match confidence
How strongly this paper was matched to this strain when the corpus was linked. It orders the list — it says nothing about the study's quality or its findings.
How we classify this →
IN_VITRO
OBSERVATIONAL
WGS
2026
IN_VITRO
2026
RCT
2026
IN_VITRO
2026
RCT
2026
RCT
2026
ANIMAL
2026
ANIMAL
2026
RCT
2026
META_ANALYSIS
2026
ANIMAL
2026
ANIMAL
2026
REVIEW
2026
WGS
2026
REVIEW
2026
RCT
2026
RCT
2026
WGS
Browse all 1,349 papers →
Elucidation of Physiological Functions and Applications of Membrane Vesicles Produced by Fermented Food Bacteria and Gut Bacteria
発酵食品細菌や腸内細菌によって生産される膜小胞の生理機能の解明と応用
· Institutional Repositories DataBase (IRDB)
Influences on colonization of infants by Bifidobacterium species
·
Assessing the Characteristics of Novel Old Order Mennonite- and Rochester-Derived Bifidobacterium infantis Strains
· UR Research (University of Rochester)
Assessing the role of folate syntrophy and folate cross-feeding in the pathobiology of infectious-inflamed milieu caused by Fusobacterium nucleatum
· Experimental and Molecular Pathology
Probiotic improves respiratory and gastrointestinal health, immune homeostasis, and gut microbiota composition in infants: a randomized controlled trial
· Frontiers in Nutrition
Aromatic lactic acid production by Bifidobacterium longum subsp. infantis is determined by cell density, substrate availability, and pH in vitro
· Applied and Environmental Microbiology
Impact of Bifidobacterium infantis supplementation on growth, health outcomes, and gut microbiome features in underweight infants from Pakistan
· Frontiers in Nutrition
A Bifidobacterium infantis-HMO synbiotic modulates metabolome in infants and protects against viral bronchiolitis and experimental asthma
· Zenodo (CERN European Organization for Nuclear Research)
Bifidobacterium Infantis Promotes FOSL1-Mediated Transcriptional Repression of VDR to Accelerate Autoimmune Pancreatitis Progression Through Activation of Oxidative Stress
· Inflammation
P0077 Bifidobacterium infantis–derived extracellular vesicles protect against NSAID-induced colonic injury in colitis models
· Journal of Crohn s and Colitis
Supplementary file 1_Impact of Bifidobacterium infantis supplementation on growth, health outcomes, and gut microbiome features in underweight infants from Pakistan.docx
· Figshare
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome
· Journal of Clinical Medicine
Early-life immune imprinting by a B. infantis–HMO synbiotic shapes infant immune signatures and protects against experimental respiratory disease
· Zenodo (CERN European Organization for Nuclear Research)
Lacto-N-neotetraose and Bifidobacterium longum ssp. infantis together shape the unique gut microbiota and metabolites of allergic mice
· Journal of Dairy Science
Bifidobacterium infantis as a microbial modulator in the first two years of life of newborns: Systematic review
· International Journal of Drug Delivery Technology
Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design
· Cell
Bifidobacterium infantis— a key (late) colonizer of the infant gut?
· mSphere
Effects of Bifidobacterium infantis M-63 on gut environment and bowel function during weaning: RCT
· Pediatric Research
Clinical benefits of Bifidobacterium infantis YLGB-1496 in modulating gut microbiota and immunity in young children
· Frontiers in Nutrition
Mapping the genomic landscape of two key human gut microbial species: Bifidobacterium infantis and Bifidobacterium longum
· Microbiome Research Reports
Discussion
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Citations
Selected papers that name this strain.
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[1]
Source →Systems-level immunomonitoring in pediatric cancer and early life development· · 2026
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[2]
PMID 41561177 →Clinical benefits of Bifidobacterium infantis YLGB-1496 in modulating gut microbiota and immunity in young children· Frontiers in Nutrition · 2026
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[3]
Source →Bifidobacterium infantis as a microbial modulator in the first two years of life of newborns: Systematic review· International Journal of Drug Delivery Technology · 2026
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[4]
PMID 42056537 →Effects of Bifidobacterium infantis M-63 on gut environment and bowel function during weaning: RCT· Pediatric Research · 2026
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[5]
Source →A Bifidobacterium infantis-HMO synbiotic modulates metabolome in infants and protects against viral bronchiolitis and experimental asthma· Zenodo (CERN European Organization for Nuclear Research) · 2026
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[6]
PMID 42137872 →Impact of Bifidobacterium infantis supplementation on growth, health outcomes, and gut microbiome features in underweight infants from Pakistan· Frontiers in Nutrition · 2026
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[7]
Source →Supplementary file 1_Impact of Bifidobacterium infantis supplementation on growth, health outcomes, and gut microbiome features in underweight infants from Pakistan.docx· Figshare · 2026
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[8]
PMID 41682832 →Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome· Journal of Clinical Medicine · 2026
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[9]
PMID 41878569 →Probiotic improves respiratory and gastrointestinal health, immune homeostasis, and gut microbiota composition in infants: a randomized controlled trial· Frontiers in Nutrition · 2026
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[10]
PMID 39940249 →Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review· Nutrients · 2025